The Role of the ω-3 Fatty Acid DHA in the Human Life Cycle
The Role of the ω-3 Fatty Acid DHA in the Human Life Cycle
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DOI：
10.1177/0148607112467821
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发表时间：
2013-01-01
影响因子：
3.4
通讯作者：
Puder, Mark
中科院分区：
文献类型：
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作者：
Carlson, Sarah J.;Fallon, Erica M.;Puder, Mark
膳食中必需的脂肪酸亚油酸(LA；omega-6)和α-亚麻酸(Ala；omega-3)的摄入对人类的生长和发育是必要的。在过去的150年里，西方的平均饮食发生了巨大的变化，以至于今天人类摄入的omega-6脂肪酸的比例比以往任何时候都要高得多。Omega-3脂肪酸在人类发育中的重要性已在胎儿和新生儿发育中得到充分证实，大脑和视网膜组织高度依赖omega-3脂肪酸，特别是二十二碳六烯酸(DHA)来调节细胞膜流动性和信号转导。在儿童时期，omega-3已被证明有助于持续的认知发展，并可能参与骨转换和脂肪生成的代谢编程。Omega-3还可能在成人神经生理学和疾病预防中发挥重要作用。(JPEN J Parenter Enteral Nutr.2013；37：15-22)
Dietary consumption of the essential fatty acids linoleic acid (LA; omega-6) and alpha-linolenic acid (ALA; omega-3) is necessary for human growth and development. In the past 150 years, the average Western diet has changed dramatically such that humans today consume a much higher proportion of omega-6 fatty acids relative to omega-3 fatty acids than ever before. The importance of omega-3 fatty acids in human development has been well established in fetal and neonatal development, with brain and retinal tissues highly dependent on omega-3 fatty acids, specifically docosahexaenoic acid (DHA) for membrane fluidity and signal transduction. In childhood, omega-3s have been shown to contribute to ongoing cognitive development and may be involved in metabolic programming of bone turnover and adipogenesis. omega-3s may also play important roles in adult neurophysiology and disease prevention. (JPEN J Parenter Enteral Nutr. 2013;37:15-22)