Maintained salivary function after brachytherapy in patients with head and neck carcinomas--evaluation using quantitative salivary gland scintigraphy.
Maintained salivary function after brachytherapy in patients with head and neck carcinomas--evaluation using quantitative salivary gland scintigraphy.
复制标题
头颈癌患者近距离放射治疗后维持唾液功能——使用定量唾液腺闪烁扫描进行评估。
作者：
Y. Murata;Lin Zhang;R. Ishida;W. Aung;S. Taura;Moinul Hossain;R. Yoshimura;M. Hoshina;H. Akaike;Takashi Sugaya;H. Shibuya
这项研究的目的是确定头颈癌患者在近距离放射治疗后的前三个月内是否出现唾液腺功能障碍。在本研究纳入的20例头颈部鳞状细胞癌患者中，11例接受了近距离放射治疗，其余9例接受了外照射。所有患者在放疗前和放疗后均行唾液腺核素扫描。比较放疗前后各主要唾液腺的放射性参数。近距离放疗组放射治疗前后各项功能参数均无明显变化。相反，外照射后，除颌下腺摄取比率(UR)外，其余参数均显著降低。由于这两种技术的照射剂量不同，这一观察是意料之中的。用于评估唾液腺功能的放射性核素技术应用于未来的调强放射治疗唾液腺保留研究，以评估放射治疗对头颈部癌症患者的急性和慢性影响。
The purpose of this study was to determine whether or not salivary gland dysfunction occurs within the first three months after brachytherapy in patients with head and neck carcinoma. Of the 20 patients with head and neck squamous cell carcinoma included in this study, 11 were treated with brachytherapy and the remaining 9 patients received external irradiation. All the patients underwent a salivary gland scintigraphy before and after radiotherapy. The scintigraphic parameters of each major salivary gland were then compared before and after the radiotherapy. In the brachytherapy group, none of the scintigraphic functional parameters showed a significant change before and after the radiotherapy. In contrast, all of the parameters with the exception of the uptake ratio (UR) of the submandibular glands significantly decreased after external irradiation. This observation was to be expected owing to the different irradiation doses administered by the two techniques. The scintigraphic technique used to evaluate salivary gland function should be used in future intensity-modulated radiation therapy salivary-gland-sparing studies in order to evaluate both the acute and chronic effects of irradiation in head and neck cancer patients.