EXCITOTOXIC CELL-DEATH
EXCITOTOXIC CELL-DEATH
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DOI：
10.1002/neu.480230915
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发表时间：
1992-11-01
期刊：
影响因子：
--
通讯作者：
CHOI, DW
中科院分区：
文献类型：
--
作者：
CHOI, DW
兴奋性毒性是指谷氨酸或相关兴奋性氨基酸在某些条件下介导中枢神经元死亡的能力，例如，在强烈暴露后。这种兴奋性毒性神经元死亡可能导致与几种人类疾病状态相关的脑或脊髓损伤的发病机制。兴奋性毒性具有显著的细胞特异性，并且在大多数情况下，由谷氨酸受体介导。平均而言，NMDA受体激活可能能够比AMPA或红藻氨酸受体激活更快地触发致死性损伤，这可能反映了诱导钙内流和随后的细胞钙超载的更大能力。兴奋性毒性死亡可能与其他形式的神经元死亡共享某些机制。
Excitotoxicity refers to the ability of glutamate or related excitatory amino acids to mediate the death of central neurons under certain conditions, for example, after intense exposure. Such excitotoxic neuronal death may contribute to the pathogenesis of brain or spinal cord injury associated with several human disease states. Excitotoxicity has substantial cellular specificity and, in most cases, is mediated by glutamate receptors. On average, NMDA receptors activation may be able to trigger lethal injury more rapidly than AMPA or kainate receptor activation, perhaps reflecting a greater ability to induce calcium influx and subsequent cellular calcium overload. It is possible that excitotoxic death may share some mechanisms with other forms of neuronal death.