Innate-Like B Cells and Their Rules of Engagement
Innate-Like B Cells and Their Rules of Engagement
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DOI：
10.1007/978-1-4614-6217-0_7
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发表时间：
2013-01-01
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影响因子：
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通讯作者：
Baumgarth, Nicole
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文献类型：
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作者：
Baumgarth, Nicole
抗体是免疫系统的组成部分。它们响应于感染或损伤而产生，但也在与抗原的任何接触之前作为所谓的天然抗体存在。本文综述了天然抗体的组织和细胞来源。它总结了最近的数据显示，B-1细胞，一种先天性的B细胞群体，在发育、库和组织位置上与大多数常规或B-2细胞不同，是稳态小鼠中天然抗体的主要贡献者。此外，他们表明，天然IgM的产生似乎主要局限于脾和骨髓中的B-1细胞群。相反，体腔中的B-1细胞，即该群体的优势部位，含有不组成性产生抗体的B-1细胞。相反，这些细胞作为快速免疫应答者，在感染后不久重新定位到次级淋巴组织并分化为细胞因子和抗体分泌细胞。因此，B-1细胞应答参与的过程不同于B-2细胞活化的过程，因为效应B-1细胞的积累不依赖于广泛的克隆扩增，而是依赖于它们的快速迁移和重新分布，这是一个在感染诱导的先天信号控制下出现的过程。
Antibodies are an integral part of the immune system. They are produced in response to an infection or insult but are also present prior to any encounter with antigen as so-called natural antibodies. This review focuses on the tissues and cellular origins of natural antibodies. It summarizes recent data showing that B-1 cells, an innate-like B cell population distinct in development, repertoire, and tissue location from the majority conventional or B-2 cells, are the main contributors of natural antibodies in mice in steady state. Furthermore, they show that natural IgM production appears largely confined to B-1 cell populations in the spleen and bone marrow. In contrast, B-1 cells in the body cavities, sites of predominance of this population, harbor B-1 cells that do not constitutively produce antibodies. Instead, these cells act as rapid immune responders that relocate to secondary lymphoid tissues and differentiate to cytokine and antibody-secreting cells shortly after an infection. Thus, the process of B-1 cell response participation is distinct from that of B-2 cell activation as the accumulation of effector B-1 cells does not rely on extensive clonal expansion, but instead on their rapid migration and redistribution, a process that appears under the control of infection-induced innate signals.