Plasticity of human stem cells in the fetal sheep model of human stem cell transplantation
Plasticity of human stem cells in the fetal sheep model of human stem cell transplantation
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DOI：
10.1007/bf02983526
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发表时间：
2004-01-01
影响因子：
2.1
通讯作者：
Zanjani, ED
中科院分区：
文献类型：
--
作者：
Almeida-Porada, G;Porada, C;Zanjani, ED
允许在正常生理条件下以及在没有遗传或损伤引起的功能障碍的情况下评估干细胞的全部潜力的实验模型将成为研究干细胞分化机制的有价值的工具。理想情况下，这样的模型还允许供体来源的组织特异性细胞的稳健形成。因为研究表明，在没有选择压力的情况下，干细胞分化为不同生发层的细胞的效率非常低，因此健康的成年动物不太可能满足这些要求。在这篇综述中，我们描述了孕早期发育中免疫前胎儿的许可方面的优势，这使我们将绵羊开发为人类干细胞可塑性的大型动物模型。 (C) 2004 年日本血液学会。
Experimental models that allow the evaluation of the full potential of stem cells under normal physiological conditions and in the absence of genetic or injury-induced dysfunction would serve as valuable tools for the study of the mechanisms underlying stem cell differentiation. Ideally, such a model would also permit the robust formation of donor-derived tissue-specific cells. Because studies have shown that the differentiation of stem cells into cells of a different germinal layer is highly inefficient in the absence of selective pressure, it is very unlikely that a healthy adult animal can fulfill these requirements. In this review, we describe the advantages of the permissive aspects of the developing preimmune fetus in the early gestational age that led us to develop the sheep as a large-animal model of human stem cell plasticity. (C) 2004 The Japanese Society of Hematology.