Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells
Antiproliferative effects of dibenzocyclooctadiene lignans isolated from Schisandra chinensis in human cancer cells
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DOI：
10.1016/j.bmcl.2007.11.082
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发表时间：
2008-01-15
影响因子：
2.7
通讯作者：
Lee, Sang Kook
中科院分区：
文献类型：
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作者：
Min, Hye-Young;Park, Eun-Jung;Lee, Sang Kook
从五味子中分离出的二苯并环辛二烯木酚素在多种人类癌细胞中显示出抗增殖作用。 C-3、C-4、C-3'和C-4'处的甲氧基、C-8'处的羟基以及联苯环和当归酰基的立体构型可能对这些活性有影响。另有研究表明，活性化合物五味子素 C 对 A549 人肺癌细胞的作用机制之一与抑制 G0/G1 期细胞周期进展有关。 (c) 2007 Elsevier Ltd. 保留所有权利。
Dibenzocyclooctadiene lignans isolated from Schisandra chinensis showed antiproliferative effects in various human cancer cells. The methoxy groups at C-3, C-4, C-3', and C-4', the hydroxyl group at C-8', and the stereo-configuration of the biphenyl ring and the angeloyl group might have influence on these activities. Additional studies indicate that one of mechanism of action of an active compound schizantherin C in A549 human lung cancer cells was related to the inhibition of cell cycle progression in G0/G1 phase. (c) 2007 Elsevier Ltd. All rights reserved.