Pathogenicity of fowl adenovirus isolated from gizzard erosions to immuno-suppressed chickens
Pathogenicity of fowl adenovirus isolated from gizzard erosions to immuno-suppressed chickens
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DOI：
10.1292/jvms.68.289
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发表时间：
2006-03-01
影响因子：
1.2
通讯作者：
Takase, K
中科院分区：
文献类型：
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作者：
Muroga, N;Taharaguchi, S;Takase, K
采用传染性法氏囊病病毒（IBDVs）或环磷酰胺（CY）预处理的SPF鸡，研究了禽腺病毒（FAV）血清型1株JM1/1对肉鸡沙囊溃疡病的致病性。在SPF鸡3日龄时经口接种经典型强毒IBDVs。孵化后CY皮下处理3 d。30日龄时口服FAV。40日龄时，对所有鸡进行放血和解剖，进行血清学和大体观察。根据其严重程度对砂囊病变进行评分。IBDV或cy处理鸡的砂囊病变评分显著高于未处理鸡。除法氏囊萎缩外，其他脏器未见明显病变。血清学上，IBDV感染或CY治疗均能高度抑制FAV抗体的产生。
Pathogenicity of a fowl adenovirus (FAV), JM1/1 strain of serotype 1 derived from gizzard erosions of a broiler chicken, was examined to specific pathogen-free (SPF) chickens pre-treated with infectious bursal disease viruses (IBDVs) or cyclophosphamide (CY). Virulent IBDVs, classical type, were inoculated orally at 3 days of age of SPF chickens. CY was treated subcutaniously for 3 days after hatch. FAV was given orally at 30 days of age. At 40 days of age, all chickens were bled and autopsied for serology and gross observation. Gizzard lesions were ranked by the scores depending on their severities. IBDV- or CY-treated chickens showed significantly higher gizzard lesion scores than non treated birds. There were no gross lesions in any other organs except for bursal atrophy. Serologically, antibody production against FAV was highly suppressed by IBDV infection or CY treatment.