MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation
MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation
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DOI：
10.1016/s0955-0674(99)00036-8
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发表时间：
1999-12-01
影响因子：
7.5
通讯作者：
Olson, E
中科院分区：
文献类型：
--
作者：
Naya, FJ;Olson, E
骨骼肌发育涉及一个多步骤的途径，在这个途径中，中胚层前体细胞响应诱导信号被选择，形成成肌细胞，这些成肌细胞随后退出细胞周期并分化。控制肌肉分化的转录回路与细胞周期机制密切相关，以至于在成肌细胞退出细胞周期之前，肌肉分化基因不会被转录。MyoD和MEF2转录因子家族的成员组合在一起，控制成肌细胞的特化、分化和增殖。最近的研究揭示了多个信号系统，这些系统通过改变MEF2的磷酸化及其与其他转录辅因子的关联来刺激和抑制肌生成。
Skeletal muscle development involves a multistep pathway in which mesodermal precursor cells are selected, in response to inductive cues, to form myoblasts that later withdraw from the cell cycle and differentiate. The transcriptional circuitry controlling muscle differentiation is intimately linked to the cell cycle machinery, such that muscle differentiation genes do not become transcribed until myoblasts have exited the cell cycle. Members of the MyoD and MEF2 families of transcription factors associate combinatorially to control myoblast specification, differentiation and proliferation. Recent studies have revealed multiple signaling systems that stimulate and inhibit myogenesis by altering MEF2 phosphorylation and its association with other transcriptional cofactors.