CD8+ cytotoxic T lymphocyte responses to lytic proteins of human herpes virus 8 in human immunodeficiency virus type 1-infected and -uninfected individuals.
CD8+ cytotoxic T lymphocyte responses to lytic proteins of human herpes virus 8 in human immunodeficiency virus type 1-infected and -uninfected individuals.
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在人类免疫缺陷病毒 1 型感染和未感染个体中，CD8 细胞毒性 T 淋巴细胞对人类疱疹病毒 8 裂解蛋白的反应。
DOI：
10.1086/315777
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
RinaldoJr,CR
中科院分区：
文献类型：
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作者：
Wang,QJ;Jenkins,FJ;Jacobson,LP;Meng,YX;Pellett,PE;Kingsley,LA;Kousoulas,KG;Baghian,A;RinaldoJr,CR
T 细胞对疱疹病毒裂解蛋白的免疫对于宿主控制感染非常重要。我们已经表征了 HHV-8 血清阳性个体中对 5 种人疱疹病毒 8 (HHV-8) 裂解蛋白同源物的细胞毒性 T 淋巴细胞 (CTL) 反应。在所有 14 名 HHV-8 血清阳性研究受试者中，无论是否感染 1 型人类免疫缺陷病毒 (HIV-1)，均检测到 HLA I 类限制性 CD8+CTL 对⩽ 1 HHV-8 裂解蛋白的反应，但在 5 名 HHV-8 血清阴性个体中均未检测到。其中 7 名同时感染 HHV-8 和 HIV-1 的研究对象比 7 名仅感染 HHV-8 的研究对象对糖蛋白 H（开放阅读框 22）具有更高的抗 CTL 反应性。此外，在感染这两种病毒的研究对象中，HIV-1 载量与糖蛋白 H 特异性 CTL 裂解之间存在很强的负相关性。 CTL 对 HHV-8 裂解蛋白的反应性可能参与宿主对 HHV-8 相关疾病（例如卡波西肉瘤）的控制。
T cell immunity to lytic proteins of herpesviruses is important in host control of infection. We have characterized the cytotoxic T lymphocyte (CTL) response to 5 human herpesvirus 8 (HHV-8) homologues of lytic proteins in HHV-8—seropositive individuals. HLA class I—restricted, CD8+CTL responses to ⩽ 1 HHV-8 lytic protein were detected in all 14 HHV-8—seropositive study subjects tested, with or without human immunodeficiency virus type 1 (HIV-1) infection, but not in any of 5 HHV-8—seronegative individuals. Seven of these study subjects with both HHV-8 and HIV-1 infection had greater anti-CTL reactivity to glycoprotein H (open-reading frame 22) than did the 7 study subjects infected only with HHV-8. Moreover, there was a strong, inverse correlation between HIV-1 load and glycoprotein H—specific CTL lysis in the study subjects infected with both viruses. CTL reactivity to HHV-8 lytic proteins may be involved in host control of HHV-8—related diseases, such as Kaposi's sarcoma.