Eukaryotic domain evolution inferred from genome comparisons
Eukaryotic domain evolution inferred from genome comparisons
复制标题
DOI：
10.1016/j.gde.2003.10.004
复制
发表时间：
2003-12-01
影响因子：
4
通讯作者：
Ponting, C
中科院分区：
文献类型：
--
作者：
Copley, RR;Goodstadt, L;Ponting, C
真核生物基因组的比较分析提供了深入了解域家族进化的模式和克里思。基因复制是家族扩张的来源，它远远超过了非编码序列中结构域的出现速度，以及结构域进入新结构的速度。似乎仅限于某些谱系的结构域家族可能是基因复制的结果，加上快速的序列多样化。如果这些家族是过去适应的证据，那么它们的功能必须与选择的基本机制有关：生物体之间的竞争。
Comparative analyses of eukaryotic genomes are providing insights into the mode and tempo of domain family evolution. Gene duplication, the source of family expansion, far exceeds the rate of emergence of domains from non-coding sequence, and the rate of recruitment of domains into novel architectures. Domain families that appear to be restricted to certain lineages are likely to be the result of gene duplication, coupled with rapid sequence diversification. If such families are evidence of past adaptation, then their functions must relate to the underlying mechanism of selection: competition among organisms.