Effects of moxibustion on dynorphin and endomorphin in rats with chronic visceral hyperalgesia
Effects of moxibustion on dynorphin and endomorphin in rats with chronic visceral hyperalgesia
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DOI：
10.3748/wjg.v16.i32.4079
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发表时间：
2010-08-28
影响因子：
4.3
通讯作者：
Wu, Huan-Gan
中科院分区：
文献类型：
--
作者：
Liu, Hui-Rong;Qi, Li;Wu, Huan-Gan
目的：目的：观察艾灸对慢性内脏痛觉过敏大鼠的镇痛作用及其对脊髓强啡肽（dynorphin，Dyn）和内吗啡肽（endomorphin，EM）含量的影响。艾灸组每天艾灸1次，连续7 d;假灸组艾灸相同穴位，但艾草非阴燃端。模型对照组和正常对照组。采用腹部退缩反射评分系统对内脏痛进行行为学评估。结果：莫西沙星能明显减轻CRD引起的内脏痛，SM组与MC组比较差异无显著性。结论：艾灸能显著提高慢性内脏痛敏大鼠的痛阈，其作用可能与增加脊髓中Dyn和EM的含量有关。(C)2010年百世登。All rights reserved.
AIM: To observe the analgesic effects of moxibustion in rats with chronic visceral hyperalgesia and its influence on the concentration of dynorphin (Dyn) and endomorphin (EM) in spinal cord.METHODS: The rat model of chronic visceral hyperalgesia was established by colorectal distention (CRD). In moxibustion (MX) group, moxibustion was applied once daily for 7 d; in sham moxibustion (SM) group, moxibustion was given to the same acupoints but with the non-smoldered end of the moxa stick. Model control (MC) group and normal control group were also studied. The scoring system of abdominal withdrawal reflex was used to evaluate visceral pain for behavioral assessment. Enzyme linked immunosorbent assay was performed to determine the concentrations of Dyn and EM in spinal cord.RESULTS: Moxibustion significantly decreased visceral pain to CRD in this rat model, and no significant difference was detected between the SM group and the MC group. In MX group, moxibustion also increased the concentrations of Dyn and EM in spinal cord, and no significant difference was found between the SM group and the MC group.CONCLUSION: Moxibustion therapy can significantly enhance the pain threshold of rats with chronic visceral hyperalgesia, and the effect may be closely related to the increased concentration of Dyn and EM in spinal cord. (C) 2010 Baishideng. All rights reserved.