[18F]Flutemetamol amyloid-beta PET imaging compared with [11C]PIB across the spectrum of Alzheimer's disease
[18F]Flutemetamol amyloid-beta PET imaging compared with [11C]PIB across the spectrum of Alzheimer's disease
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DOI：
10.1007/s00259-013-2564-y
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发表时间：
2014-02-01
影响因子：
9.1
通讯作者：
Hayakawa, Hideki
中科院分区：
文献类型：
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作者：
Hatashita, Shizuo;Yamasaki, Hidetomo;Hayakawa, Hideki
目的是通过使用F-18标记的匹兹堡化合物B（PI B）衍生物[F-18]氟替米托（FMM）的正电子发射断层扫描（PET）成像来鉴定阿尔茨海默病（AD）谱中的淀粉样蛋白β（A β）沉积，并比较[F-18]FMM和[C-11] PI B PET成像之间的A β沉积。68名轻度认知障碍（MCI）受试者，41名老年健康对照（HC）（年龄为千分之一日元56），11名年轻HC（年龄为千分之一货币符号45）和10名过渡HC（年龄为46-55）。所有166名受试者在注射后85分钟接受了30分钟静态[F-18]FMM PET、60分钟动态[C-11]PIB PET和认知测试。[F-18]目视评估FMM扫描，并在共配准MRI（小脑皮质作为参考区域）上识别的感兴趣区域中定量定义标准化摄取值比率（SUVR）。36例AD患者中35例PIB扫描阳性，41例老年HC患者中36例PIB扫描阴性。[F-18]FMM扫描在区分AD患者和老年HC受试者方面的灵敏度为97.2%，特异性为85.3%，对于年轻和过渡HC受试者的特异性为100%。[C-11]PIB扫描结果相同。阅片员间一致性极佳（kappa评分= 0.81）。AD患者的皮质FMM SUVR显著大于老年HC受试者（1.76 +/- 0.23 vs 1.30 +/- 0.26，p < 0.01）。MCI患者中，68例SUVR呈双峰分布，其中29例（42.6%）扫描阳性。皮质FMM SUVR值与PIB DVR强烈相关（r = 0.94，n = 145，p < 0.001）。[F-18]FMM PET成像可检测患者沿着从正常认知状态到AD痴呆的连续体中的A β沉积，并区分AD患者和HC受试者，与[C-11]PIB PET相似。
The aim was to identify the amyloid beta (A beta) deposition by positron emission tomography (PET) imaging with the F-18-labeled Pittsburgh compound B (PIB) derivative [F-18]flutemetamol (FMM) across a spectrum of Alzheimer's disease (AD) and to compare A beta deposition between [F-18]FMM and [C-11]PIB PET imaging.The study included 36 patients with AD, 68 subjects with mild cognitive impairment (MCI), 41 older healthy controls (HC) (aged a parts per thousand yen56), 11 young HC (aged a parts per thousand currency sign45), and 10 transitional HC (aged 46-55). All 166 subjects underwent 30-min static [F-18]FMM PET 85 min after injection, 60-min dynamic [C-11]PIB PET, and cognitive testing. [F-18]FMM scans were assessed visually, and standardized uptake value ratios (SUVR) were defined quantitatively in regions of interest identified on coregistered MRI (cerebellar cortex as a reference region). The PIB distribution volume ratios (DVR) were determined in the same regions.Of 36 AD patients, 35 had positive scans, while 36 of 41 older HC subjects had negative scans. [F-18]FMM scans had a sensitivity of 97.2 % and specificity of 85.3 % in distinguishing AD patients from older HC subjects, and a specificity of 100 % for young and transitional HC subjects. The [C-11]PIB scan had the same results. Interreader agreement was excellent (kappa score = 0.81). The cortical FMM SUVR in AD patients was significantly greater than in older HC subjects (1.76 +/- 0.23 vs 1.30 +/- 0.26, p < 0.01). Of the MCI patients, 68 had a bimodal distribution of SUVR, and 29 of them (42.6 %) had positive scans. Cortical FMM SUVR values were strongly correlated with PIB DVR (r = 0.94, n = 145, p < 0.001).[F-18]FMM PET imaging detects A beta deposition in patients along the continuum from normal cognitive status to dementia of AD and discriminates AD patients from HC subjects, similar to [C-11]PIB PET.