Variability in the recurrence rate at first follow-up cystoscopy after TUR in stage Ta T1 transitional cell carcinoma of the bladder: A combined analysis of seven EORTC studies
Variability in the recurrence rate at first follow-up cystoscopy after TUR in stage Ta T1 transitional cell carcinoma of the bladder: A combined analysis of seven EORTC studies
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DOI：
10.1016/s0302-2838(02)00068-4
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发表时间：
2002-05-01
期刊：
影响因子：
23.4
通讯作者：
Sylvester, RJ
中科院分区：
文献类型：
--
作者：
Brausi, M;Collette, L;Sylvester, RJ
目的：为了评估复发率在第一次随访膀胱镜检查（RR-FFC）后，经尿道切除术（TUR）在Ta T I期膀胱cancer.Methods的患者机构之间的变异性：共2410例患者从7 EORTC III期试验1979年和1989年之间进行。根据患者是否接受了辅助膀胱内治疗，分别分析了单个和多个肿瘤的患者。对于单一肿瘤患者，未接受任何膀胱内辅助治疗的患者的发生率为3.4%至20.6%，接受膀胱内辅助治疗的患者为0%至15.4%，而接受辅助治疗的多肿瘤患者的发生率为7.4%至45.8%。随着时间的推移，有一个轻微的下降，在复发率为单一肿瘤的患者，特别是在那些接受辅助intravesicletherapeutic.Conclusions：对于这两个患者与单一和多个肿瘤，复发的患者的百分比在膀胱TUR后的第一次随访膀胱镜检查机构之间的差异很大，不能解释的因素进行了评估。这表明，由个别外科医生进行的TUR的质量可能是负责任的。(C)2002 Elsevier Science B. V.保留所有权利。
Objectives: To assess the variability between institutions in the recurrence rate at the first follow-up cystoscopy (RR-FFC) after transurethral resection (TUR) in patients with stage Ta T I bladder cancer.Methods: A total of 2410 patients from seven EORTC phase III trials conducted between 1979 and 1989 were included. Patients with single and with multiple tumors were analyzed separately according to whether or not they received adjuvant intravesical treatment.Results: The RR-FFC varied greatly between institutions. For patients with a single tumor, it ranged from 3.4% to 20.6% for patients not receiving any intravesical adjuvant treatment and from 0% to 15.4% in those receiving it. In patients with multiple tumors who had adjuvant treatment, it varied between 7.4% and 45.8%. There was a slight decrease over time in the recurrence rate for patients with single tumors, particularly in those receiving adjuvant intravesical treatment.Conclusions: For both patients with single and with multiple tumors, the percentage of patients with a recurrence in the bladder at the first follow-up cystoscopy after TUR varies substantially between institutions and cannot be explained by the factors that were assessed. It is suggested that the quality of the TUR performed by the individual surgeons may be responsible. (C) 2002 Elsevier Science B.V. All rights reserved.