Flexible, Stretchable and Implantable PDMS Encapsulated Cable for Implantable Medical Device
Flexible, Stretchable and Implantable PDMS Encapsulated Cable for Implantable Medical Device
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DOI：
10.1007/s13534-011-0033-8
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发表时间：
2011-08-01
影响因子：
4.6
通讯作者：
Lee, Sang-Hoon
中科院分区：
文献类型：
--
作者：
Kim, Sung Hwan;Moon, Jin-Hee;Lee, Sang-Hoon
目的为了方便患者和提高患者的生活质量，以及无栓系的诊断和治疗，各种商业植入式医疗设备被开发出来。这些设备需要可植入的电缆，这些电缆连接设备的每个部分，以进行经皮能量或信号传输。对于长时间植入人体，应该是安全、坚固、长期可操作的，没有失败。介绍了一种植入型聚二甲基硅氧烷(PDMS)涂层光缆。方法以聚二甲基硅氧烷(PDMS)为封装材料，研制出一种生物相容性好、柔韧耐用的光缆。为了评估电缆的性能，进行了几项测试。泄漏试验证实，使用PDMS的涂层足以防止体液对导线的入侵。拉伸试验、扭转耐久试验和弯曲耐久试验证明了其机械耐久性和运动健壮性。监测耐久性试验中记录的电阻变化，以验证电缆在移动过程中的电气稳定性。进行8周的皮下组织植入实验，观察植入电缆的生物相容性。结果与结论该电缆具有良好的力学稳定性和生物相容性，可用于长期植入的医疗器械。
Purpose Diverse commercial implantable medical devices were developed for the convenience and life-quality of patients, and tether-free diagnostics and therapeutics. Those devices need implantable cable, which connects each part of their devices for transcutaneous energy or signal transfer. For prolonged implantation into human body, it should be safe, robust, and be long-term operable without failure. In this paper, we introduce an implantable PDMS-coated cable.Methods By using PDMS as an encapsulation material, we developed a biocompatible, flexible and durable cable. Several tests were carried out for the evaluation of cable performance. Leakage test confirmed that coating using PDMS was sufficient to prevent the invasion of body fluid to conducting wire. Tensile test, torsion-durability test and bending-durability test demonstrated its mechanical durability and robustness to motion. The resistance variation recorded in the durability test was monitored to verify the electrical stability during movement of cable. Experiments of subcutaneous tissue implantation for 8 weeks were performed to observe the degree of biocompatibility as an implantable cable.Results & conclusions Our cable was mechanically stable and biocompatible enough to be used for long term implantable medical devices.