Tryptophan-niacin metabolism in liver cirrhosis rat caused by carbon tetrachloride.
Tryptophan-niacin metabolism in liver cirrhosis rat caused by carbon tetrachloride.
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四氯化碳所致肝硬化大鼠色氨酸-烟酸代谢。
DOI：
10.3177/jnsv.45.459
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发表时间：
1999
影响因子：
1.6
通讯作者：
H. Sanada
中科院分区：
文献类型：
--
作者：
Y. Egashira;Ayano Isagawa;Tomoko Komine;E. Yamada;T. Ohta;K. Shibata;H. Sanada
我们研究了四氯化碳（CCl4）诱导肝硬化大鼠色氨酸-烟酸代谢的变化。每周两次注射CCl4（0.5或1 mL 50%橄榄油溶液/kg体重），持续1或2个月，同时给予苯巴比妥水。测定了烟酰胺（Nam）及其代谢物的尿排泄物。结果，无论实验周期（1个月和2个月）或给药量如何，CCl4处理组中Nam、N1-甲基-4-吡啶酮-3-甲酰胺（4-Py）、Nam + N1-甲基烟酰胺（MNA）+ N1-甲基-2-吡啶酮-5-甲酰胺（2-Py）+ 4-Py的尿排泄量均低于未处理组（对照）。 CCl4（0.5 和 1 mL）。此外，我们还研究了 CCl4 处理的大鼠中色氨酸-烟酸代谢的哪条途径受到影响。结果表明，本实验中CCl4处理可能抑制MNA→4-Py反应。
We investigated the change of tryptophan-niacin metabolism induced by carbon tetrachloride (CCl4) in rats with liver cirrhosis. The rats were injected with CCl4 (0.5 or 1 mL of 50% olive oil solution/kg body weight) twice a week for 1 or 2 mo and given phenobarbital water simultaneously. The urinary excretions of nicotinamide (Nam) and its metabolites were assayed. As the result, the urinary excretion of Nam, N1-methyl-4-pyridone-3-carboxamide (4-Py), Nam + N1-methylnicotinamide (MNA) + N1-methyl-2-pyridone-5-carboxamide (2-Py) + 4-Py was lower in the CCl4-treated groups than in the non-treated group (control) regardless of the experimental period (1 mo and 2 mo) or dosing amount of CCl4 (0.5 and 1 mL). Moreover, we investigated which pathway of tryptophan-niacin metabolism was affected in CCl4-treated rat. As the result, the possibility that the MNA-->4-Py reaction is inhibited by CCl4 treatment was suggested in this experiment.
影响因子：
3.8
作者：
EDWARDS, MJ;KELLER, BJ;THURMAN, RG
通讯作者：
THURMAN, RG