Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex
Injury-induced neural stem/progenitor cells in post-stroke human cerebral cortex
复制标题
DOI：
10.1111/j.1460-9568.2009.07043.x
复制
发表时间：
2010-01-01
影响因子：
3.4
通讯作者：
Taguchi, Akihiko
中科院分区：
文献类型：
--
作者：
Nakayama, Daisuke;Matsuyama, Tomohiro;Taguchi, Akihiko
越来越多的证据表明中风后神经发生加速，并且在实验动物模型中，这种内源性神经发生的支持已被证明可改善中风结局。本研究分析了尸检人脑中心源性栓塞后脑卒中后的大脑皮质。诱导nestin和musashi-1阳性细胞，潜在的神经干/祖细胞，观察缺血性病变部位从中风后第1天。这两个细胞群存在于不同的位置，并显示不同的时间分布的标志物表达。然而，在中风后90天，在先前缺血的区域中没有观察到存活的分化的成熟神经细胞。与最近关于在啮齿动物模型中诱导中风后大脑皮层中神经发生的报道一致，目前的数据表明在人类大脑皮层中存在区域再生反应。此外，观察强调支持内源性神经干/祖细胞在中风后人脑中的存活和分化的潜在重要性。
Increasing evidence points to accelerated neurogenesis after stroke, and support of such endogenous neurogenesis has been shown to improve stroke outcome in experimental animal models. The present study analyses post-stroke cerebral cortex after cardiogenic embolism in autoptic human brain. Induction of nestin- and musashi-1-positive cells, potential neural stem/progenitor cells, was observed at the site of ischemic lesions from day 1 after stroke. These two cell populations were present at distinct locations and displayed different temporal profiles of marker expression. However, no surviving differentiated mature neural cells were observed by 90 days after stroke in the previously ischemic region. Consistent with recent reports of neurogenesis in the cerebral cortex after induction of stroke in rodent models, the present current data indicate the presence of a regional regenerative response in human cerebral cortex. Furthermore, observations underline the potential importance of supporting survival and differentiation of endogenous neural stem/progenitor cells in post-stroke human brain.