Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson’s disease through autophagy induction
Quantum dots protect against MPP+-induced neurotoxicity in a cell model of Parkinson’s disease through autophagy induction
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DOI：
10.1007/s11426-016-0103-7
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发表时间：
2016-10
期刊：
影响因子：
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通讯作者：
Lu Wang;Xiaoming Li;Yuping Han;Ting Wang;Yun Zhao;Aldalbahi Ali;Nahed N E El-Sayed;Jiye Shi-Jiye
中科院分区：
文献类型：
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作者：
Lu Wang;Xiaoming Li;Yuping Han;Ting Wang;Yun Zhao;Aldalbahi Ali;Nahed N E El-Sayed;Jiye Shi-Jiye
自噬是一种基本的细胞过程，它分解受损的细胞器和异常的蛋白质。自噬的失调涉及神经退行性疾病（包括帕金森病（PD））的发病机制。刺激自噬的药理学化合物可以在PD模型中提供神经保护。纳米颗粒已成为自噬的调节剂，并已在疾病的辅助治疗中进行了测试。在本研究中，我们探索了量子点（QD）在帕金森病细胞模型中诱导自噬的作用。CdTe/CdS/ZnS量子点对MPP+诱导的分化的大鼠嗜铬细胞瘤PC 12细胞的损伤具有保护作用，包括细胞活力降低、凋亡和PD特征蛋白α-Synuclein的积累。量子点的保护功能是自噬依赖的。此外，我们研究了量子点和自噬途径之间的相互作用，并确定beclin 1是量子点诱导自噬的重要因素。我们的研究结果揭示了量子点在神经退行性疾病治疗诊断中的新前景。
Autophagy is a basic cellular process that decomposes damaged organelles and aberrant proteins. Dysregulation of autophagy is implicated in pathogenesis of neurodegenerative disorders, including Parkinson’s disease (PD). Pharmacological compounds that stimulate autophagy can provide neuroprotection in models of PD. Nanoparticles have emerged as regulators of autophagy and have been tested in adjuvant therapy for diseases. In this present study, we explore the effects of quantum dots (QDs) that can induce autophagy in a cellular model of Parkinson’s disease. CdTe/CdS/ZnS QDs protect differentiated rat pheochromocytoma PC12 cells from MPP+-induced cell damage, including reduced viability, apoptosis and accumulation of α-Synuclein, a characteristic protein of PD. The protective function of QDs is autophagy-dependent. In addition, we investigate the interaction between quantum dots and autophagic pathways and identify beclin1 as an essential factor for QDs-induced autophagy. Our results reveal new promise of QDs in the theranostic of neurodegenerative diseases.