ETHNICITY AND PSYCHOPHARMACOLOGY - BRIDGING THE GAP
ETHNICITY AND PSYCHOPHARMACOLOGY - BRIDGING THE GAP
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DOI：
10.1016/s0193-953x(18)30045-5
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发表时间：
1995-09-01
影响因子：
1.7
通讯作者：
POLAND, RE
中科院分区：
文献类型：
--
作者：
LIN, KM;ANDERSON, D;POLAND, RE
过去40年的临床观察和调查结果一再表明，各种精神和非精神药物的剂量需求和副作用特征存在巨大的跨种族和跨国差异。已观察到所有主要类别的精神药物以及各种其他药物在不同种族群体中具有不同的作用。造成这些种族差异的机制包括药代动力学（包括蛋白结合）、药效学（受体偶联反应）和人格特征。药代动力学的种族差异已进一步证明在某些情况下是由遗传因素引起的，在其他情况下是由环境因素（如饮食）引起的。本文就这些问题及其临床意义作一简要综述。
Clinical observations and survey findings during the past four decades have repeatedly suggested the existence of dramatic cross-ethnic and cross-national differences in the dose requirement and side-effect profiles of various psychotropic and nonpsychotropic medications. All major classes of psychotropic medications as well as a variety of other pharmacologic agents have been observed to have differential effects in different ethnic groups. Mechanisms responsible for these ethnic differences include pharmacokinetics (including protein-binding), pharmacodynamics (receptor-coupled responses), and personality traits. Ethnic differences in pharmacokinetics have been demonstrated further to be caused by genetic factors in some circumstances and environmental factors (such as diet) in others. These issues as well as their clinical implications are reviewed briefly in this article.