Hypoxia-inducible factor 1 and breast cancer metastasis
Hypoxia-inducible factor 1 and breast cancer metastasis
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DOI：
10.1631/jzus.b1400221
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发表时间：
2015-01-01
影响因子：
5.1
通讯作者：
Zhang, Hua-feng
中科院分区：
文献类型：
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作者：
Liu, Zhao-ji;Semenza, Gregg L.;Zhang, Hua-feng
越来越多的证据表明，在癌症发展过程中至关重要的缺氧微环境在调节乳腺癌进展和转移中起着关键作用。缺氧诱导因子1（HIF-1），缺氧反应的主调节器，在这些过程中的作用已被广泛研究。本文综述了HIF-1在乳腺癌细胞转移中的作用，特别是对转移过程中上皮-间质转化（EMT）、侵袭、外渗和转移灶形成等关键环节的影响。我们还讨论了HIF-1调节的非编码RNA在乳腺癌转移中的作用，以及通过靶向HIF-1通路治疗乳腺癌的机会。
Accumulating evidence has shown that the hypoxic microenvironment, which is critical during cancer development, plays a key role in regulating breast cancer progression and metastasis. The effects of hypoxia-inducible factor 1 (HIF-1), a master regulator of the hypoxic response, have been extensively studied during these processes. In this review, we focus on the roles of HIF-1 in regulating breast cancer cell metastasis, specifically its effects on multiple key steps of metastasis, such as epithelial-mesenchymal transition (EMT), invasion, extravasation, and metastatic niche formation. We also discuss the roles of HIF-1-regulated non-coding RNAs in breast cancer metastasis, and therapeutic opportunities for breast cancer through targeting the HIF-1 pathway.