Effects of helicobacter pylori on tumor microenvironment and immunotherapy responses.
Effects of helicobacter pylori on tumor microenvironment and immunotherapy responses.
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幽门螺杆菌对肿瘤微环境和免疫治疗反应的影响
DOI：
10.3389/fimmu.2022.923477
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
--
作者：
幽门螺杆菌与胃癌有密切关系。幽门螺杆菌持续感染时，可在胃粘膜内形成一个有利于其生存和菌落形成的微环境。肿瘤基质细胞参与了这一过程，包括肿瘤相关巨噬细胞、间充质干细胞、肿瘤相关成纤维细胞和髓源性抑制细胞等，免疫检查点也受到幽门螺杆菌感染的调控。幽门螺杆菌毒力因子还可以作为免疫原或佐剂来引发或增强免疫应答，表明其在疫苗开发和肿瘤免疫治疗中的潜在应用。这篇综述强调了幽门螺杆菌对免疫微环境的影响及其在肿瘤免疫治疗反应中的潜在作用。
Helicobacter pylori is closely associated with gastric cancer. During persistent infection, Helicobacter pylori can form a microenvironment in gastric mucosa which facilitates the survival and colony formation of Helicobacter pylori. Tumor stromal cells are involved in this process, including tumor-associated macrophages, mesenchymal stem cells, cancer-associated fibroblasts, and myeloid-derived suppressor cells, and so on. The immune checkpoints are also regulated by Helicobacter pylori infection. Helicobacter pylori virulence factors can also act as immunogens or adjuvants to elicit or enhance immune responses, indicating their potential applications in vaccine development and tumor immunotherapy. This review highlights the effects of Helicobacter pylori on the immune microenvironment and its potential roles in tumor immunotherapy responses.
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影响因子：
3.7
作者：
El-Zaatari M;Kao JY;Tessier A;Bai L;Hayes MM;Fontaine C;Eaton KA;Merchant JL
通讯作者：
Merchant JL
影响因子：
--
作者：
Chakrabarti, Jayati;Holokai, Loryn;Zavros, Yana
通讯作者：
Zavros, Yana
影响因子：
3.1
作者：
Beswick, Ellen J.;Pinchuk, Irina V.;Reyes, Victor E.
通讯作者：
Reyes, Victor E.
影响因子：
11.5
作者：
Alfaro, Carlos;Teijeira, Alvaro;Melero, Ignacio
通讯作者：
Melero, Ignacio
影响因子：
1
作者：
Fakhari S;Kalantar E;Nikzaban M;Hakhamneshi MS;Fathi F;Nikkhoo B;Rahmani MR;Beiraghdar M;Jalili A
通讯作者：
Jalili A