Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor
Fabrication of octacalcium phosphate block through a dissolution-precipitation reaction using a calcium sulphate hemihydrate block as a precursor
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DOI：
10.1007/s10856-018-6162-1
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发表时间：
2018-10-01
影响因子：
3.7
通讯作者：
Ishikawa, Kunio
中科院分区：
文献类型：
--
作者：
Sugiura, Yuki;Munar, Melvin L.;Ishikawa, Kunio
尽管磷酸八钙（OCP）粉末和胶原蛋白/明胶复合材料作为骨替代品表现出良好的潜力，但迄今为止尚未制造出OCP块。在这项研究中，制造的OCP块的可行性进行了评估，通过溶解-沉淀反应使用硫酸钙半水合物（CSH）块作为前体。当块体浸入磷酸盐溶液中时，其组成变为OCP的组成，而其结构保持不变。OCP块的径向拉伸强度（MPa）为1.0 +/-0.2MPa。OCP块的大孔隙率和微孔隙率分别为33.4 +/- 4.5%和69.0 +/-1.6%。新骨与OCP块连接良好，植入后2周，OCP块部分被骨替代。植入4周后，OCP块的表面几乎被新骨覆盖，并且大约30%的块被新骨替代，而在用作对照的羟基磷灰石（HAp）块的情况下没有观察到骨替代。结论：OCP块有可能适合作为人工骨替代物。
Although octacalcium phosphate (OCP) powder and a collagen/gelatin composite demonstrate good potential as bone substitutes, an OCP block has not been fabricated to date. In this study, the feasibility of fabricating an OCP block was evaluated through a dissolution-precipitation reaction using a calcium sulfate hemihydrate (CSH) block as a precursor. When the block was immersed in a phosphate salt solution, its composition changed to that of OCP, while its structure was maintained. The diametral tensile strength (DTS) of the OCP block was 1.0 +/- 0.2 MPa. The macroporosity and microporosity of the OCP block were 33.4 +/- 4.5% and, 69.0 +/- 1.6%, respectively. New bone attached well to the OCP block, and this block was partially replaced by bone 2 weeks after implantation. Four weeks after implantation, the surface of the OCP block was nearly covered with new bone and similar to 30% of the block was replaced by new bone, while no replacement by bone was observed in the case of a hydroxyapatite (HAp) block used as a control. It is concluded that OCP blocks are potentially suitable for their use as artificial bone substitutes.