Recent advances in the preclinical development of responsive MRI contrast agents capable of detecting hydrogen peroxide
Recent advances in the preclinical development of responsive MRI contrast agents capable of detecting hydrogen peroxide
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能够检测过氧化氢的响应性 MRI 造影剂临床前开发的最新进展
DOI：
10.1016/j.jinorgbio.2022.111763
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发表时间：
2022
影响因子：
3.9
通讯作者：
Goldsmith, Christian R.
中科院分区：
文献类型：
--
作者：
Karbalaei, Sana;Goldsmith, Christian R.
在这篇综述中，我们专注于临床前开发和研究的配合物，作为磁共振成像（MRI）造影剂传感器过氧化氢。已经开发了氧化还原响应探针，其提供可以通过传统T1加权的1H、19F和化学交换饱和转移MRI检测的信号。传感器还可以根据信号的变化是否对应于金属离子或有机配体的氧化来分类。
In this review, we focus on the preclinical development and study of coordination complexes that act as magnetic resonance imaging (MRI) contrast agent sensors for hydrogen peroxide. Redox-responsive probes have been developed that provide signals that can be detected through traditionalT1-weighted1H,19F, and Chemical Exchange Saturation Transfer MRI. The sensors can also be classified with respect to whether the change in the signal corresponds to the oxidation of the metal ion or the organic ligand.