Vascular Mimicry: Concepts and Implications for Anti-Angiogenic Therapy.
Vascular Mimicry: Concepts and Implications for Anti-Angiogenic Therapy.
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DOI：
10.2174/2211552811201020133
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发表时间：
2012-06-01
期刊：
影响因子：
--
通讯作者：
Dudley AC
中科院分区：
文献类型：
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作者：
Dunleavey JM;Dudley AC
与正常组织一样，实体瘤依赖于血管网络来供应血液、氧气和营养物质。肿瘤血管是通过常见的新生血管形成过程形成的，例如内皮发芽。然而，一些肿瘤具有可供选择的和意想不到的新血管形成机制。在一个称为“血管模仿”的过程中，肿瘤创建了自己的肿瘤细胞内衬通道，用于液体运输，而不依赖于典型的血管生成模式。这些肿瘤细胞衬里的管道可能表达内皮选择性标记物和抗凝因子，其允许与宿主内皮的吻合。在这篇综述中，我们探讨了血管模仿研究的现状，强调了最近的证据，这些证据强化了肿瘤细胞这种不寻常能力的假设。此外，我们解决了血管拟态提供了一种机制，使肿瘤可以逃避抗血管生成治疗的理论可能性。
As in normal tissues, solid tumors depend on vascular networks to supply blood, oxygen, and nutrients. Tumor blood vessels are formed by common processes of neovascularization for example endothelial sprouting. However, some tumors have alternative and unexpected mechanisms of neovascularization at their disposal. In a process termed “vascular mimicry,” tumors create their own, tumor cell-lined channels for fluid transport independent of typical modes of angiogenesis. These tumor cell-lined conduits may express endothelial-selective markers and anti-coagulant factors which allow for anastamosis with host endothelium. In this review, we explore the current status of vascular mimicry research, highlighting recent evidence which strengthens the hypothesis for this unusual ability of tumor cells. Furthermore, we address the theoretical possibility that vascular mimicry provides a mechanism whereby tumors could escape anti-angiogenic therapies.