Robot-assisted thoracoscopic surgery versus thoracotomy for c-N2 stage NSCLC: short-term outcomes of a randomized trial
Robot-assisted thoracoscopic surgery versus thoracotomy for c-N2 stage NSCLC: short-term outcomes of a randomized trial
复制标题
机器人辅助胸腔镜手术与开胸手术治疗 c-N2 期 NSCLC：随机试验的短期结果
DOI：
10.21037/tlcr.2019.11.31
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发表时间：
2019-12-01
影响因子：
4
通讯作者：
Xu, Wenrong
中科院分区：
文献类型：
--
作者：
Huang, Jia;Li, Chongwu;Xu, Wenrong
背景资料：机器人辅助胸腔镜手术（RAI'S）治疗早期非小细胞肺癌（NSCLC）的安全性和短期疗效先前已得到证实;然而，N2期NSCLC的大鼠几乎没有评估。方法：将113例临床确诊为cN2期非小细胞肺癌的患者随机分为两组，即大鼠组和开胸组。大鼠组采用da芬奇手术系统行肺叶切除及纵隔淋巴结清扫术，开胸组行肺叶切除及纵隔淋巴结清扫术。结果：113例受试者（大鼠组58例，开胸组55例）的数据符合分析条件。最初接受机器人辅助肺叶切除术的5名患者由于广泛的胸膜粘连和设备问题在术中转为开放手术。此外，1例接受机器人辅助手术的受试者在术前死于肺栓塞。与开胸手术相比，大鼠手术中失血量较少（86.3 ± 41.1 vs. 165.7 ± 46.4 mL，P
Background: Safety and short-term efficacy of robot-assisted thoracoscopic surgery (RAI'S) for early-stage non-small cell lung cancer (NSCLC) have been previously proven; however, RATS for N2 stage NSCLC was barely evaluated. The aim of this randomized controlled trial (RCT) was to explore the short-term outcome of RATS for cN2 stage NSCLC.Methods: Total of 113 patients who were diagnosed with clinically single cN2 stage NSCLC were enrolled and randomly assigned to RATS and thoracotomy groups. The patients in RATS group were treated by lobectomy and mediastinal lymph node dissection using the da Vinci Surgical System, while the patients in thoracotomy group underwent lobectomy and mediastinal lymph node dissection from. And, short-term outcomes were analyzed statistically.Results: The data from 113 subjects (58 in RATS and 55 in thoracotomy groups) were eligible for analyses. Five patients who received robot-assisted lobectomy initially was converted intraoperatively to open operation due to extensive pleural adhesion and equipment issues. And, one subject underwent robotassisted surgery was died preoperatively due to pulmonary embolism. Compared with thoracotomy, RATS was associated with less intraoperative blood loss (86.3 +/- 41.1 vs. 165.7 +/- 46.4 mL, P