Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.
Human B-cell alloantigens DC1, MT1, and LB12 are identical to each other but distinct from the HLA-DR antigen.
复制标题
人 B 细胞同种抗原 DC1、MT1 和 LB12 彼此相同，但与 HLA-DR 抗原不同。
DOI：
10.1073/pnas.78.7.4566
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发表时间：
1981
影响因子：
11.1
通讯作者：
Strominger,JL
中科院分区：
文献类型：
--
作者：
Shackelford,DA;Mann,DL;vanRood,JJ;Ferrara,GB;Strominger,JL
一些人 B 类淋巴母细胞系表现出至少两种类型的 Ia 样抗原。一种抗原由 HLA-DR 的同种抗血清定义，另一种抗原由同种抗血清和针对特异性 DC1、MT1 (MB1) 和 LB12 的单克隆抗体定义，这些特异性与 HLA-DR 连锁不平衡。 DC1分子的亚基与DR分子的亚基不同。两个分子的轻链在结构上都是多态性的。
Some human B-lymphoblastoid cell lines are shown to express at least two types of Ia-like antigens. One antigen is defined by alloantisera to HLA-DR, and the other antigen is defined by alloantisera and a monoclonal antibody to the specificities DC1, MT1 (MB1), and LB12, which are in linkage disequilibrium with HLA-DR. The subunits of the DC1 molecule differ from those of the DR molecule. The light chains of both molecules are structurally polymorphic.