Stage at presentation of breast cancer in Luanda, Angola - a retrospective study
Stage at presentation of breast cancer in Luanda, Angola - a retrospective study
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DOI：
10.1186/s12913-015-1092-9
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发表时间：
2015-10-15
影响因子：
2.8
通讯作者：
Santos, Lucio Lara
中科院分区：
文献类型：
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作者：
Lopes, Lygia Vieira;Miguel, Fernando;Santos, Lucio Lara
背景：预计到 2020 年，全球每年将出现 1500 万新发癌症病例，其中 100 万发生在非洲。对非洲国家癌症趋势的了解还远远不够，迫切需要改进癌症预防工作。本研究的目的是了解安哥拉罗安达乳腺癌的临床和病理特征；我们还提供有助于该国乳腺癌护理规划的高质量信息。方法：从2006年至2014年从安哥拉癌症控制研究所检索乳腺癌病例数据。对于2009年诊断的女性（5年随访），收集了目前的人口统计、临床和病理信息，即诊断时的年龄、产次、病理诊断所用的方法、肿瘤病理特征、疾病阶段和治疗。进行描述性统计。结果：2009年诊断出患有乳腺癌的女性中位年龄为47岁（范围25-89岁）。最常见的临床表现是乳房肿胀伴腋窝淋巴结转移（44.9%），其次是大于5厘米的肿块（14.2%）和肿块（12.9%）。浸润性导管癌是主要的组织学类型（81.8%）。只有 10.1% 的癌症病例具有良好分化的组织学分级。癌症大多在晚期被诊断出来（66.7% 在 III 期，11.1% 在 IV 期）。讨论：在这项研究中，乳腺癌是在非常晚期被诊断出来的。尽管它报告的数据来自安哥拉罗安达的一个癌症中心，但它强调了早期诊断和提高认识的必要性。根据本文提出的与乳腺癌诊断和治疗相关的主要挑战，我们提出了一个现实的框架，该框架将允许实施乳腺癌护理计划，该框架建立在基于合作、教学、审计、良好实践和卫生服务组织的强大网络下。结论：安哥拉迫切需要一项乳腺癌早期诊断计划。
Background: It is expected that, by 2020, 15 million new cases of cancer will occur every year in the world, one million of them in Africa. Knowledge of cancer trends in African countries is far from adequate, and improvements in cancer prevention efforts are urgently needed. The aim of this study was to characterize breast cancer clinically and pathologically at presentation in Luanda, Angola; we additionally provide quality information that will be useful for breast cancer care planning in the country.Methods: Data on breast cancer cases were retrieved from the Angolan Institute of Cancer Control, from 2006 to 2014. For women diagnosed in 2009 (5-years of follow-up), demographic, clinical and pathological information, at presentation, was collected, namely age at diagnosis, parity, methods used for pathological diagnoses, tumor pathological characteristics, stage of disease and treatment. Descriptive statistics were performed.Results: The median age of women diagnosed with breast cancer in 2009 was 47 years old (range 25-89). The most frequent clinical presentation was breast swelling with axillary lymph nodes metastasis (44.9 %), followed by a mass larger than 5 cm (14.2 %) and lump (12.9 %). Invasive ductal carcinoma was the main histologic type (81.8 %). Only 10.1 % of cancer cases had a well differentiated histological grade. Cancers were diagnosed mostly at advanced stages (66.7 % in stage III and 11.1 % in stage IV).Discussion: In this study, breast cancer was diagnosed at a very advanced stage. Although it reports data from a single cancer center in Luanda, Angola it reinforces the need for early diagnosis and increasing awareness. According to the main challenges related to breast cancer diagnosis and treatment herein presented, we propose a realistic framework that would allow for the implementation of a breast cancer care program, built under a strong network based on cooperation, teaching, audit, good practices and the organization of health services.Conclusion: Angola needs urgently a program for early diagnosis of breast cancer.