1.11-P20Intergenerational transmission of health disparities among Turkish-origin residents in Germany: role of maternal stress and stress biology during pregnancy. A study protocol
1.11-P20Intergenerational transmission of health disparities among Turkish-origin residents in Germany: role of maternal stress and stress biology during pregnancy. A study protocol
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1 11-P20德国土耳其裔居民健康差异的代际传播：怀孕期间孕产妇压力和压力生物学的作用研究方案
DOI：
10.1093/eurpub/cky048.044
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发表时间：
2018
影响因子：
4.4
通讯作者：
Entringer S
中科院分区：
文献类型：
--
作者：
Scholaske L;Lindner-Matthes D;Kurt M;Duman E;Sahbaz C;Spallek J;Entringer S
背景：土耳其裔移民是德国最大的移民群体之一，与大多数人口相比，他们表现出更高的社会劣势。研究已经阐明了社会不利因素在生物学上影响人一生健康的潜在机制。然而，相对较少的是知道它的影响是如何跨generations.Aims的研究：为了阐明产妇的迁移状态和社会经济地位的影响，压力相关的母亲-胎盘-胎儿（MPF）的生物过程，整个妊娠期和随后的婴儿出生和健康outcomes.Methods：我们正在进行一项纵向队列研究N= 450儿童-母亲的二对一系列措施，通过妊娠和出生的第一年的生活。我们拟定的研究人群将包括德国的土耳其裔女性、德国的德国女性、居住在土耳其的土耳其女性及其后代。研究访问从怀孕的第二个三个月到生命的第一年结束进行，以评估产妇的社会经济和移民相关信息，心理健康，营养，医疗风险变量，以及来自产妇血液和唾液样本的MPF压力生物标志物。婴儿人体测量的措施，发展成果和唾液中的压力标记物进行评估，在整个生命的第一年。分析：我们将测试具体的假设，移民背景，社会经济地位和MPF压力生物学之间的关联。我们将进一步量化产妇移民背景和社会障碍相关的强积金压力生物学措施怀孕和儿童health outcomes.Discussion的关联：这是第一次研究胎儿编程的健康差距，重点是土耳其裔妇女在德国。这项研究的意义和影响来自于更好地了解改变少数群体和弱势群体疾病脆弱性的潜在机制的重要性。
Background:Turkish-origin immigrants constitute one of the biggest migration groups in Germany where they exhibit higher levels of social disadvantage when compared to the majority population. Research has elucidated the underlying mechanisms by which social disadvantage is biologically embedded to impact health over the lifespan. However, relatively little is known about how its effects are transmitted across generations.Aims of the study:To elucidate the effects of maternal migration status and socioeconomic status on stress-related maternal-placental-foetal (MPF) biological processes across gestation and on subsequent infant birth and health outcomes.Methods:We are conducting a longitudinal cohort study of N= 450 child-mother dyads with serial measures across gestation and birth through the first year of life. Our proposed study population will include approximately equal numbers of Turkish-origin women in Germany, German women in Germany, Turkish women living in Turkey and their offspring. Study visits are conducted from the second trimester of pregnancy to the end of the first year of life to assess maternal socio-economic and migration-related information, psychological well-being, nutrition, medical risk variables, and MPF stress biology markers from maternal blood and saliva samples. Infant anthropometric measures, developmental outcomes and stress markers in saliva are assessed throughout the first year of life.Analyses:We will test specific hypotheses regarding the association between migration background, socioeconomic status and MPF stress biology. We will furthermore quantify the association of maternal migration background-and social disadvantage-related MPF stress biology measures on pregnancy and child health outcomes.Discussion:This is the first study on foetal programming of health disparities with a focus on Turkish-origin women in Germany. The significance and impact of this study derives from the importance of achieving a better understanding of underlying mechanisms that alter disease vulnerability in minority and disadvantaged populations.