PRESERVATIVES IN EYE DROPS
PRESERVATIVES IN EYE DROPS
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滴眼剂中的防腐剂
DOI：
10.1111/j.1755-3768.1969.tb08132.x
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发表时间：
1969
影响因子：
3.4
通讯作者：
A. Malmborg
中科院分区：
文献类型：
--
作者：
R. Barkman;M. Germanis;G. Karpe;A. Malmborg
近几十年来，滴眼液在使用时无菌的重要性越来越受到重视。因此，无菌制备、灭菌和添加防腐剂是其生产中的三个重要步骤。另一个重要的问题是，液滴在这样的容器中分配和发送，即，防止内容物的感染与它们的使用相关。在过去的20年中，大多数药典都对滴眼液的无菌性提出了要求。Pharmacopoea Nordica（1965）规定，滴眼液应无菌制备，如果储存，应无菌，并添加适当的防腐剂，除非药物具有杀菌作用。在其他国家的药典中，也规定或建议滴眼液应含有防腐剂。许多工作都致力于寻找合适的防腐剂（如。G . Dale等人1949，休森& Styron 1949，西奥多& Feinstein 1952，1953，Brewer等人1953，Goldstein 1953，Klein等人1954，Grote & Woods 1955，Lawrence 1955，Murphy等人1955，Riegelman等人1955，1956，1958，Clausen 1957，Deeb & Boenigh 1958，Whittet 1959，Runti 1960，安德森等人1964，Hugo & Foster 1964）。合适的防腐剂所需的特性之一是其对细菌以及真菌和病毒具有快速致死作用（麦克弗森& Wood
The importance of eye drops being sterile on use has been increasingly emphasized in recent decades. Consequently, aseptic preparation, sterilization and addition of preservatives are three steps of consequence in their manufacture. Another matter of significance is for the drops to be dispensed and dispatched in such containers that infection of the contents is prevented in connexion with their use. Demands for the sterility of eye drops have been introduced into most pharmacopoeias during the past 20 years. Pharmacopoea Nordica (1 965) prescribes that the eye drops should be prepared aseptically, be sterile if they are stored, and a suitable preservative added unless the drug has a bactericidal effect. In the pharmacopoeias of other countries as well, it is prescribed or at any rate recommended that eye drops should contain preservatives. Much work has been devoted to finding suitable preservatives (e. g . Dale et al. 1949, Hughson & Styron 1949, Theodore & Feinstein 1952, 1953, Brewer et al. 1953, Goldstein 1953, Klein et al. 1954, Grote & Woods 1955, Lawrence 1955, Murphy et a1 1955, Riegelman et al. 1955, 1956, 1958, Clausen 1957, Deeb & Boenigh 1958, Whittet 1959, Runti 1960, Anderson et al. 1964, Hugo & Foster 1964). One of the properties required of a suitable preservative is that it has a rapid lethal effect on bacteria, as well as on fungi and viruses (McPherson & Wood