Dietary Restriction Improves Fitness of Aging Parents But Reduces Fitness of Their Offspring in Nematodes.
Dietary Restriction Improves Fitness of Aging Parents But Reduces Fitness of Their Offspring in Nematodes.
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在线虫中，饮食限制可以改善年迈父母的健康状况，但会降低其后代的健康状况。
DOI：
10.1093/gerona/glz276
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Maklakov,AlexeiA
中科院分区：
文献类型：
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作者：
Mautz,BrianS;Lind,MartinI;Maklakov,AlexeiA
饮食限制（DR）是一种行之有效的延长物种寿命的干预措施。最近的研究表明，DR 驱动的寿命延长可以是免费的，这引发了对衰老进化理论的核心观点的质疑。然而，延长父母的寿命可能会降低后代的健康水平。这种代际权衡常常被忽视，但却可以解释长寿的“缺失成本”。在这里，我们使用线虫 Caenorhabditis remaneito 测试禁食 DR 对雌性及其后代健康的影响。与持续获得食物的女性相比，连续 6 天被剥夺食物的女性在重新接触食物后，生育力、生存率和抗应激能力确实有所提高。然而，DR 母亲的后代早期和终生的生育力降低，生长速度减慢，性成熟时体型较小。这些发现支持体细胞投资和配子之间的直接权衡，挑战了体细胞维持增加和繁殖受损可以解耦的假设。
Dietary restriction (DR) is a well-established intervention to extend lifespan across taxa. Recent studies suggest that DR-driven lifespan extension can be cost-free, calling into question a central tenant of the evolutionary theory of aging. Nevertheless, boosting parental longevity can reduce offspring fitness. Such intergenerational trade-offs are often ignored but can account for the “missing costs” of longevity. Here, we use the nematodeCaenorhabditis remaneito test for effects of DR by fasting on fitness of females and their offspring. Females deprived of food for 6 days indeed had increased fecundity, survival, and stress resistance after re-exposure to food compared with their counterparts with constant food access. However, offspring of DR mothers had reduced early and lifetime fecundity, slower growth rate, and smaller body size at sexual maturity. These findings support the direct trade-off between investment in soma and gametes challenging the hypothesis that increased somatic maintenance and impaired reproduction can be decoupled.