Effect of the initial dose of foot-and-mouth disease virus on the early viral dynamics within pigs
Effect of the initial dose of foot-and-mouth disease virus on the early viral dynamics within pigs
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DOI：
10.1098/rsif.2008.0434
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发表时间：
2009-10-06
影响因子：
3.9
通讯作者：
Woolhouse, Mark
中科院分区：
文献类型：
--
作者：
Howey, Richard;Quan, Melvyn;Woolhouse, Mark
本文研究了受感染猪体内口蹄疫 (FMD) 的早期病毒动态。使用现有的宿主内模型，我们研究了个体差异是否可以通过口蹄疫病毒初始剂量的影响来解释。为此，我们考虑了血液中口蹄疫病毒基因组浓度（病毒载量）的实验数据。在这个实验中，12头猪接种了三种不同剂量的FMD病毒之一：低剂量；低剂量；中等的;或高。在大约 11 天的时间过程中，每 8 小时记录一次病毒载量测量值。该模型是一组具有以下变量的确定性微分方程：病毒载量；间隙中的病毒；以及可用于感染、感染和未感染的上皮细胞的比例。该模型分别拟合每只动物的数据，并且同时拟合仅改变初始剂量的所有动物的数据。我们表明，数据的总体趋势可以通过仅改变初始剂量来解释。初始剂量越高，可检测到的病毒载量就越早出现。
This paper investigates the early viral dynamics of foot-and-mouth disease (FMD) within infected pigs. Using an existing within-host model, we investigate whether individual variation can be explained by the effect of the initial dose of FMD virus. To do this, we consider the experimental data on the concentration of FMD virus genomes in the blood (viral load). In this experiment, 12 pigs were inoculated with one of three different doses of FMD virus: low; medium; or high. Measurements of the viral load were recorded over a time course of approximately 11 days for every 8 hours. The model is a set of deterministic differential equations with the following variables: viral load; virus in the interstitial space; and the proportion of epithelial cells available for infection, infected and uninfected. The model was fitted to the data for each animal individually and also simultaneously over all animals varying only the initial dose. We show that the general trend in the data can be explained by varying only the initial dose. The higher the initial dose the earlier the development of a detectable viral load.