Tumor necrosis factor-alpha in synovial fluid and plasma from patients with chronic connective tissue disease and its relation to temporomandibular joint pain
Tumor necrosis factor-alpha in synovial fluid and plasma from patients with chronic connective tissue disease and its relation to temporomandibular joint pain
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DOI：
10.1016/s0278-2391(00)90015-6
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发表时间：
2000-05-01
影响因子：
1.9
通讯作者：
Kopp, S
中科院分区：
文献类型：
--
作者：
Nordahl, S;Alstergren, P;Kopp, S
目的：本研究旨在测定慢性炎症性结缔组织病患者颞下颌关节（TMJ）滑液（sf - tnf - α）和血浆（p - tnf - α）中肿瘤坏死因子- α (tnf - α)水平，探讨其与颞下颌关节疼痛、痛觉过敏和异位性痛的关系。患者和方法：24例诊断为慢性炎症性结缔组织病和TMJ疼痛的患者纳入研究。记录视觉模拟量表、TMJ压痛和下颌运动疼痛，并测量压痛阈值和压痛耐受性杠杆。分析TMJ滑液样本和血浆中tnf - α及其与TMJ疼痛、痛觉过敏和异位性疼痛相关的水平。结果：24例患者中有8例颞下颌关节滑液中tnf - α的含量明显高于同一次就诊时的血浆水平。sf - tnf - α的存在与最大自主张口时TMJ疼痛和TMJ后触诊压痛呈显著正相关。结论：慢性炎症性结缔组织病患者的TMJ滑膜发生tnf - α的局部生成。下颌运动疼痛和颞下颌关节后触诊压痛（异常性痛）与SF-TNF α水平有关。(C) 2000美国口腔颌面外科医师协会。
Purpose: The purpose of this study was to determine the level of tumor necrosis factor-alpha (TNF-alpha) in the temporomandibular joint (TMJ) synovial fluid (SF-TNF-alpha) and blood plasma (P-TNF-alpha) of patients with chronic inflammatory connective tissue disease and investigate its relation to TMJ pain, hyperalgesia, and allodynia.Patients and Methods: Twenty-four patients with a diagnosis of chronic inflammatory connective tissue disease and TMJ pain were included in the study. Visual analog scale, tenderness of the TMJ, and pain at mandibular movements were registered, and the pressure pain threshold and pressure pain tolerance levers were measured. TMJ synovial fluid samples and blood plasma were analyzed for TNF-alpha and the levels related to TMJ pain, hyperalgesia, and allodynia.Results: TNF-alpha was present in the TMJ synovial fluid of 8 of 24 patients at levels significantly exceeding those in plasma at the same visit. The presence of SF-TNF-alpha showed a significant positive correlation to TMJ pain at maximum voluntary mouth opening and tenderness to posterior palpation of the TMJ.Conclusion: Local production of TNF-alpha occurs in the TMJ synovium of patients with chronic inflammatory connective tissue disease. Pain on mandibular movement and tenderness on posterior palpation (allodynia) of the TMJ is related to the level of SF-TNF alpha. (C) 2000 American Association of Oral and Maxillofacial Surgeons.