New insulin-mimetic zinc (II) complexes;: Bis-maltolato zinc(II) and bis-2-hydroxypyridine-N-oxide zinc(II) with Zn(O4) coordination mode
New insulin-mimetic zinc (II) complexes;: Bis-maltolato zinc(II) and bis-2-hydroxypyridine-N-oxide zinc(II) with Zn(O4) coordination mode
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DOI：
10.1246/cl.2000.874
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发表时间：
2000-08-05
影响因子：
1.6
通讯作者：
Kojima, Y
中科院分区：
文献类型：
--
作者：
Yoshikawa, Y;Ueda, E;Kojima, Y
具有锌(O-4)配位方式的锌(II)配合物具有胰岛素仿生活性。发现双麦芽糖酸锌(II)(锌(Mal)(2))络合物呈八面体结构，并在一个单元中呈四方锥构型。与VOSO4(IC50=1.00 mM)和ZnSO4(IC50=0.81 mM)相比，锌(MAL)(2)(IC_(50)=0.59 mM)和双-2-羟基吡啶-N-氧化物锌(II)(IC_(50)=0.41 mM)具有更高的胰岛素仿生活性，对大鼠脂肪细胞释放游离脂肪酸的抑制浓度为50%。
Zinc(II) complexes with a Zn(O-4) coordination mode were found to have insulinomimetic activity. A bis-maltolato zinc(II) (Zn(Mal)(2)) complex was revealed to be in an octahedral and a square pyramidal geometries in a unit fell. Both Zn(Mal)(2) (IC50 = 0.59 mM) and bis-2-hydroxypyridine-N-oxide zinc(II) (IC50 = 0.41 mM) complexes exhibited higher insulinomimetic activity than VOSO4(IC50 = 1.00 mM) and ZnSO4(IC50 = 0.81 mM) in terms of IC50 values, which show 50% inhibition concentration of the complex in the free fatty acids release from rat adipocytes.