Nonfasting Triglycerides and Risk of Ischemic Stroke in the General Population
Nonfasting Triglycerides and Risk of Ischemic Stroke in the General Population
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DOI：
10.1002/ana.22384
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发表时间：
2008-11-12
影响因子：
120.7
通讯作者：
Nordestgaard, Borge G.
中科院分区：
文献类型：
--
作者：
Freiberg, Jacob J.;Tybjaerg-Hansen, Anne;Nordestgaard, Borge G.
背景甘油三酯在缺血性卒中风险中的作用仍存在争议。最近，一个强关联之间的水平升高的非空腹甘油三酯，这表明残余脂蛋白的存在，并增加缺血性心脏病的风险。目的测试的假设，即水平升高的非空腹甘油三酯与缺血性中风在一般人群。设计，设置和参与者哥本哈根市心脏研究，一个前瞻性，丹麦人群队列研究始于1976年，随访至2007年7月.参与者是13956名年龄在20到93岁之间的男性和女性。一项横断面研究包括9637名参加1991- 1994年前瞻性研究检查的个体.主要结果测量前瞻性研究：非空腹甘油三酯的基线水平，基线和随访检查时的其他危险因素，以及缺血性卒中的发生率.横断面研究：非空腹甘油三酯水平、残余胆固醇水平和缺血性卒中的患病率。结果在前瞻性研究的13956名参与者中，1529名发生缺血性卒中。缺血性卒中的累积发病率随着非空腹甘油三酯水平的增加而增加（对数秩趋势，P
Context The role of triglycerides in the risk of ischemic stroke remains controversial. Recently, a strong association was found between elevated levels of nonfasting triglycerides, which indicate the presence of remnant lipoproteins, and increased risk of ischemic heart disease.Objective To test the hypothesis that increased levels of nonfasting triglycerides are associated with ischemic stroke in the general population.Design, Setting, and Participants The Copenhagen City Heart Study, a prospective, Danish population - based cohort study initiated in 1976, with follow- up through July 2007. Participants were 13 956 men and women aged 20 through 93 years. A cross- sectional study included 9637 individuals attending the 1991- 1994 examination of the prospective study.Main Outcome Measures Prospective study: baseline levels of nonfasting triglycerides, other risk factors at baseline and at follow- up examinations, and incidence of ischemic stroke. Cross- sectional study: levels of nonfasting triglycerides, levels of remnant cholesterol, and prevalence of ischemic stroke.Results Of the 13 956 participants in the prospective study, 1529 developed ischemic stroke. Cumulative incidence of ischemic stroke increased with increasing levels of nonfasting triglycerides ( log- rank trend, P