Temporal sampling requirements for reference region modeling of DCE-MRI data in human breast cancer.
Temporal sampling requirements for reference region modeling of DCE-MRI data in human breast cancer.
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DOI：
10.1002/jmri.21812
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发表时间：
2009-07
影响因子：
4.4
通讯作者：
Yankeelov, Thomas E.
中科院分区：
文献类型：
--
作者：
Planey, Catherine R.;Welch, E. Brian;Xu, Lei;Chakravarthy, A. Bapsi;Gatenby, J. Christopher;Freehardt, Darla;Mayer, Ingrid;Meszeoly, Ingrid;Kelley, Mark;Means-Powell, Julie;Gore, John C.;Yankeelov, Thomas E.
评估动态对比增强MRI （DCE-MRI）数据与参考区（RR）模型在人乳腺癌中的定量分析所需的时间采样要求。通过6个DCE-MRI采集的一系列药代动力学参数值、动脉输入函数和时间采样，模拟研究了RR模型估计的药代动力学参数（Ktrans和ve）的误差。我们获取了12名乳腺癌患者的DCE-MRI数据，并使用原始分辨率数据（16.4秒）估计参数，并与下采样32.8秒和65.6秒的数据进行比较。仿真结果表明，在大多数参数组合中，RR模型提取参数的误差小于20%，时间采样差至35.6秒。实验结果表明，与下采样的32.8秒数据相比，在16.4秒时间分辨率下获得的数据中，Ktrans和ve估计值之间具有很高的相关性：回归线的斜率为1.025 (95% CI: 1.021, 1.029)， Ktrans的Pearson相关r = 0.943 (CI: 0.940, 0.945), 1.023 （CI: 1.021）。1.025), r = 0.979 （CI: 0.978, 0.980）。对于64秒时间分辨率数据，Ktrans的结果为0.890 (CI: 0.894, 0.905), r = 0.8645 (CI: 0.858, 0.871)， ve的结果为1.041 (CI:1.039, 1.043), r = 0.970 （CI:0.968, 0.971）。RR分析允许显著减少时间采样要求，这有助于分析在实际情况下获得的DCE-MRI数据。
To assess the temporal sampling requirements needed for quantitative analysis of dynamic contrast enhanced MRI (DCE-MRI) data with a reference region (RR) model in human breast cancer. Simulations were used to study errors in pharmacokinetic parameters (Ktrans and ve) estimated by the RR model using six DCE-MRI acquisitions over a range of pharmacokinetic parameter values, arterial input functions, and temporal samplings. DCE-MRI data were acquired on 12 breast cancer patients and parameters were estimated using the native resolution data (16.4 second) and compared to downsampled 32.8 second and 65.6 second data. Simulations show that, in the majority of parameter combinations, the RR model results in an error less than 20% in the extracted parameters with temporal sampling as poor as 35.6 seconds. The experimental results show a high correlation between Ktrans and ve estimates from data acquired at 16.4 second temporal resolution compared to the downsampled 32.8 second data: the slope of the regression line was 1.025 (95% CI: 1.021, 1.029), Pearson's correlation r = 0.943 (CI: 0.940, 0.945) for Ktrans, and 1.023 (CI: 1.021. 1.025), r = 0.979 (CI: 0.978, 0.980) for ve. For the 64 second temporal resolution data the results were: 0.890 (CI: 0.894, 0.905), r = 0.8645, (CI: 0.858, 0.871) for Ktrans, and 1.041 (CI:1.039, 1.043), r = 0.970 (CI:0.968, 0.971) for ve. RR analysis allows for a significant reduction in temporal sampling requirements and this lends itself to analyze DCE-MRI data acquired in practical situations.
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