EFFECT OF ATRIAL-NATRIURETIC-FACTOR ON BRONCHOMOTOR TONE IN THE NORMAL HUMAN AIRWAY
EFFECT OF ATRIAL-NATRIURETIC-FACTOR ON BRONCHOMOTOR TONE IN THE NORMAL HUMAN AIRWAY
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DOI：
10.1042/cs0790051
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发表时间：
1990-07-01
期刊：
影响因子：
6
通讯作者：
THOMSON, NC
中科院分区：
文献类型：
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作者：
HULKS, G;JARDINE, AG;THOMSON, NC
1.哮喘患者支气管扩张对心房利钠因子的反应。我们希望确定正常受试者的气道是否以类似的方式作出反应。2.气道阻力的变化，确定特定的气道传导，在8名正常人静脉输注的心钠素在0.5，2和10 pmol min-1 kg-1的剂量进行了测量。3.尽管外周静脉血中心房利钠因子的最大平均（SEM）血浆水平为597（62）pg/ml，但在任何输注速率下均未观察到对比气道传导率的显著影响。4.第二项研究使用了8名原始受试者中的6名，并采用了50 pmol心钠素min-1 kg-1的药理剂量。这产生的平均血浆水平为2056 pg/ml，比气道传导率平均增加31%。5.结论是，药理学，而不是病理生理，血浆心钠素升高可能会显着改变正常人的支气管张力。
1. Asthmatic patients bronchodilate in response to infused atrial natriuretic factor. We wished to determine whether the airways of normal subjects responded in a similar way. 2. Changes in airway resistance, as determined by specific airway conductance, were measured in eight normal subjects in response to intravenous infusion of atrial natriuretic factor at doses of 0.5, 2 and 10 pmol min-1 kg-1. 3. No significant effect was observed on specific airway conductance at any rate of infusion despite maximum mean (SEM) plasma levels of 597 (62) pg of atrial natriuretic factor/ml in peripheral venous blood. 4. A second study was performed using six of the eight original subjects and employing a pharmacological dose of 50 pmol of atrial natriuretic factor min-1 kg-1. This produced mean plasma levels of 2056 pg/ml and a mean increase of 31% in specific airway conductance. 5. It is concluded that pharmacological, but not pathophysiological, elevations of plasma atrial natriuretic factor may significantly alter bronchomotor tone in normal subjects.