On‐line optimization of biotechnological processes: I. Application to open algal pond
On‐line optimization of biotechnological processes: I. Application to open algal pond
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生物技术工艺在线优化：一、在开放式藻池中的应用
DOI：
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发表时间：
1990
影响因子：
3.8
通讯作者：
S. Ben
中科院分区：
文献类型：
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作者：
Hugo Guterman;S. Ben
已经开发并测试了一种新的在线优化和控制程序，适用于无法获得精确数学模型的生物技术系统。所提出的方法基于自动系统使用改进的单纯形算法在线搜索最佳操作条件，该算法添加了一些功能以允许实时操作。单纯形算法是分层软件包的上层，其他层是成本评估、控制、数据采集和信号处理。该优化方法在用于培养钝顶螺旋藻的实验室小池中进行了测试。受控参数为光强度、光密度、pH 值和温度。所提出的优化方法可以应用于其他生物过程，只要可以测量和控制相关变量并且可以用数学方法定义成本函数。
A new on‐line optimization and control procedure applicable to biotechnological systems for which a precise mathematical model is unavailable has been developed and tested. The proposed approach is based on an online search for optimum operating conditions by an automatic system using a modified simplex algorithm to which several features have been added to permit real time operation. The simplex algorithm is the upper level of a hierarchical software package in which the other levels are cost evaluation, control, data acquisition, and signal processing. The optimization method was tested in a laboratory minipond for the cultivation of Spirulina platensis. The controlled parameters were light intensity, optical density, pH, and temperature. The proposed optimization method can be applied to other biological processes provided that the pertinent variables can be measured and controlled and the cost function can be defined mathematically.