Pericardial fat and echocardiographic measures of cardiac abnormalities: the Jackson Heart Study.
Pericardial fat and echocardiographic measures of cardiac abnormalities: the Jackson Heart Study.
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DOI：
10.2337/dc10-1312
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发表时间：
2011-02
期刊：
影响因子：
16.2
通讯作者：
Taylor HA
中科院分区：
文献类型：
--
作者：
Liu J;Fox CS;Hickson DA;May WL;Ding J;Carr JJ;Taylor HA
心包脂肪组织（PAT）是邻近心肌的区域脂肪库，可能介导肥胖与心脏左心室（LV）异常之间的复杂关系。我们试图在杰克逊心脏研究 (JHS) 中评估 PAT 与左心室异常超声心动图测量的关联。 2007 年至 2009 年，来自 JHS 的总共 1,414 名非裔美国人（35% 为男性；平均年龄 58 岁）接受了 PAT 和腹部内脏脂肪组织 (VAT) 的计算机断层扫描评估，并在 2000 年至 2004 年期间接受了超声心动图检查。超声心动图测量了左心房 (LA) 内径、左心室质量、左心室射血分数 (LVEF) 和 E 波检查速度与 A 波速度比（E/A 比）与 PAT、VAT、BMI 和腰围 (WC) 的关系。所有肥胖指标均与 LA 直径和 LV 质量呈正相关，与 E/A 比值呈负相关（P = 0.02 至 0.0001），但与 LVEF 无关（P = 0.36–0.61）。在女性中，PAT 每增加 1-SD，我们观察到与较高的 LV 质量（9.0 ± 1.7 gm，P = 0.0001）和 LA 直径（1.0 ± 0.1 mm，P = 0.0001）相关。然而，与 VAT（P = 0.65 [LV 质量]；P = 0.26 [LA 直径]）相比，PAT 与心脏测量值之间的关联程度相似，并且与 BMI（P = 0.002 [LV 质量]；P = 0.01 [LA 直径]）和 WC（P = 0.009 [LA 直径]）相比较小。 PAT 与心脏 LV 异常的超声心动图测量相关，但这种关联并不比其他肥胖测量更强。
Pericardial adipose tissue (PAT), a regional fat depot adjacent to the myocardium, may mediate the complex relation between obesity and cardiac left ventricular (LV) abnormalities. We sought to evaluate the association of PAT with echocardiographic measures of LV abnormalities in the Jackson Heart Study (JHS). A total of 1,414 African Americans (35% men; mean age 58 years) from the JHS underwent computed tomographic assessment of PAT and abdominal visceral adipose tissue (VAT) from 2007 to 2009 and echocardiography examination between 2000 and 2004. Echocardiographic measures of left atrial (LA) internal diameter, LV mass, LV ejection fraction (LVEF), and E-wave velocity-to-A-wave velocity ratio (E/A ratio) were examined in relation to PAT, VAT, BMI, and waist circumference (WC). All adiposity measures were positively correlated with LA diameter and LV mass and negatively correlated with E/A ratio (P = 0.02 to 0.0001) and were not with LVEF (P = 0.36–0.61). In women, per 1-SD increment of PAT, we observed association with higher LV mass (9.0 ± 1.7 gm, P = 0.0001) and LA diameter (1.0 ± 0.1 mm, P = 0.0001). However, the magnitude of the association between PAT and cardiac measures was similar compared with VAT (P = 0.65 [LV mass]; P = 0.26 [LA diameter]) and was smallercompared with BMI (P = 0.002 [LV mass]; P = 0.01 [LA diameter]) and WC (P = 0.009 [LA diameter]). PAT is correlated with echocardiographic measures of cardiac LV abnormalities, but the association is not stronger than other adiposity measures.