Circadian cortisol rhythms in healthy boys and girls: Relationship with age, growth, body composition, and pubertal development
Circadian cortisol rhythms in healthy boys and girls: Relationship with age, growth, body composition, and pubertal development
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DOI：
10.1210/jc.82.2.536
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发表时间：
1997-02-01
影响因子：
5.8
通讯作者：
AlbertssonWikland, K
中科院分区：
文献类型：
--
作者：
Knutsson, U;Dahlgren, J;AlbertssonWikland, K
为了了解下丘脑-垂体-肾上腺轴的正常功能与青春期发育、生长（体重和身高）、身体组成和性别的关系，并获得儿童血清皮质醇浓度的参考数据，我们研究了235名健康儿童（162名男孩和73名女孩）血清皮质醇的基本昼夜节律。年龄范围在2.2-18.5岁之间。在1400,1800,2200,0200,0400,0600和1000小时采集静脉血样本分析血清皮质醇。没有证据表明时间位置或昼夜皮质醇节律水平与年龄，生长或身体组成有关。然而，我们在健康人群中发现了广泛的皮质醇水平，个体平均日水平在100-510 nmol/L之间。无论日均皮质醇水平是高还是低，青春期内和青春期之间的重复测量表明，个体在整个青春期发育过程中都保持在他或她的皮质醇范围内。总之，本研究表明1)血清皮质醇水平与年龄或性别无关；2)内源性平均日皮质醇水平存在较大且显著的个体间差异；3)尽管个体之间存在差异，但皮质醇水平与身体成分或生长速度之间没有相关性。这表明皮质醇水平的变化是正常体内平衡的一种表达，而不是病理。
To provide basic information on the normal functioning of the hypothalamus-pituitary-adrenal axis in relation to pubertal development, growth (weight and height), body composition, and gender and to obtain reference data for serum cortisol concentrations in children, we investigated the basal circadian rhythm of serum cortisol in a group of 235 healthy children (162 boys and 73 girls). The age range was between 2.2-18.5 yr. Serum cortisol was analyzed from venous blood samples taken at 1400, 1800, 2200, 0200, 0400, 0600, and 1000 h. No evidence was found for differences in temporal placement or level of the circadian cortisol rhythm in relation to age, growth, or body composition. However, we found a broad range of cortisol levels in a healthy population, with individual mean diurnal ranging from 100-510 nmol/L. Regardless of high or low mean diurnal cortisol levels, repeated measurements within and between pubertal stages indicated that an individual remains in his or her cortisol range throughout pubertal development. In conclusion, the present study shows that 1) serum cortisol levels do not correlate with either age or gender; 2) there is a large and significant interindividual variability in endogenous mean diurnal cortisol levels; and 3) despite this variability between individuals, there is no correlation between cortisol levels and either body composition or growth rate. This suggests that the variability in cortisol levels is an expression of normal homeostasis rather than pathology.