Intakes of apples or apple polyphenols decease plasma values for oxidized low-density lipoprotein/beta2-glycoprotein I complex
Intakes of apples or apple polyphenols decease plasma values for oxidized low-density lipoprotein/beta2-glycoprotein I complex
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DOI：
10.1016/j.jff.2012.08.010
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发表时间：
2013
影响因子：
5.6
通讯作者：
Shi Zhao;J. Bomser;E. Joseph;R. DiSilvestro
中科院分区：
文献类型：
--
作者：
Shi Zhao;J. Bomser;E. Joseph;R. DiSilvestro
已经提出了许多饮食调整来降低心血管疾病的风险，但这些调整通常需要大量的努力。相比之下，在健康的中年人中，每天只吃一个苹果，持续4周，大大降低了氧化低密度脂蛋白/β 2-糖蛋白I复合物（oxLDL-β2GPI）的血浆浓度，这是动脉粥样硬化的一个潜在因素。苹果多酚提取物胶囊也降低了OxLDL-β2GPI值，尽管没有整个苹果那么多。安慰剂胶囊没有效果。OxLDL-β2GPI浓度随苹果或苹果多酚提取物摄入量的降低并不伴随着红细胞超氧化物歧化酶1（一种可抑制脂蛋白氧化的抗氧化酶）活性的增加。总之，一个容易实现的饮食干预对动脉粥样硬化危险因素有重要影响，部分通过多酚，但不一定通过超氧化物歧化酶。
Many dietary modifications have been proposed to reduce cardiovascular disease risk, but often, these modifications require substantial effort. In contrast, in healthy middle aged adults, consumption of just one apple/day for 4weeks drastically lowered plasma concentrations of oxidized low-density lipoprotein/beta2-glycoprotein I complex (oxLDL-β2GPI), a proposed contributor to atherosclerosis. OxLDL-β2GPI values were also lowered by capsules of apple polyphenol extract, though not as much as with whole apples. Placebo capsules had no effect. The decrease in OxLDL-β2GPI concentrations in response to intake of apples or apple polyphenol extract were not accompanied by increased erythrocyte activities of superoxide dismutase 1, an antioxidant enzyme that can inhibit lipoprotein oxidation. In summary, an easily accomplished dietary intervention had a major effect on an atherosclerosis risk factor, in part via polyphenols, but not necessarily via superoxide dismutase.