Hypoxia-Induced Glioma-Derived Exosomal miRNA-199a-3p Promotes Ischemic Injury of the Peritumoral Neurons in Glioma by Inhibiting the mTOR Pathway: A Novel Ischemic Injury Mechanism in Peritumoral Neurons
Hypoxia-Induced Glioma-Derived Exosomal miRNA-199a-3p Promotes Ischemic Injury of the Peritumoral Neurons in Glioma by Inhibiting the mTOR Pathway: A Novel Ischemic Injury Mechanism in Peritumoral Neurons
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缺氧诱导的胶质瘤来源的外泌体 miRNA-199a-3p 通过抑制 mTOR 途径促进胶质瘤中瘤周神经元的缺血性损伤:瘤周神经元的一种新的缺血性损伤机制
DOI:
10.2139/ssrn.3559529
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发表时间:
2020-03
期刊:
影响因子:
--
通讯作者:
Rong Xie
中科院分区:
文献类型:
--
作者:
Jian-Lan Zhao;Bo Tan;Gong Chen;Zhuo-Ying Du;Qiang Yuan;Jian Yu;Yi-Rui Sun;Xiao-Mu Li;Jin Hu;Rong Xie
Background: It has been reported that the peritumoral hypoxic microenvironment could promote the injury of peritumoral neurons in glioma, but underlying mechanisms are unknown. We hypothesized that the exosomes, exosomal miRNAs and mTOR signaling pathway
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影响因子:
6.1
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Ratajczak, MZ