Solitary splenic metastasis from nasopharyngeal carcinoma: a case report and systematic review of the literature.
Solitary splenic metastasis from nasopharyngeal carcinoma: a case report and systematic review of the literature.
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DOI：
10.1186/s12957-016-0941-2
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发表时间：
2016-07-15
影响因子：
3.2
通讯作者：
de'Angelis N
中科院分区：
文献类型：
--
作者：
Genova P;Brunetti F;Bequignon E;Landi F;Lizzi V;Esposito F;Charpy C;Calderaro J;Azoulay D;de'Angelis N
孤立性脾转移很少见，鼻咽癌是最不常见的原发肿瘤之一。本研究旨在描述一例罕见的鼻咽癌孤立性单发脾转移病例，并评估文献中报道的孤立性鼻咽癌脾转移病例的数量。我们描述一位56岁男性患者，有鼻咽癌病史，放化疗后完全缓解。完全缓解三个月后，正电子发射断层扫描/计算机断层扫描显示脾损害为高代谢，其他区域的代谢活动没有增加。在腹腔镜脾切除术后，病理报告证实为鼻咽型未分化癌的单一脾转移。术后一段时间平安无事。我们还使用MEDLINE和谷歌学者数据库对文献进行了系统的回顾。对所有报道鼻咽癌脾转移病例的文献进行评估，无论是否有组织学证实。文献检索共获得15篇相关文献，其目的和方法各不相同，仅描述了25例鼻咽癌脾转移病例。目前的综述显示，鼻咽癌的孤立性脾转移是一种罕见的事件，但在影像上有脾病变且有鼻咽癌原发或复发病史的患者应考虑这种情况。没有证据支持切除脾对鼻咽癌孤立性脾转移患者的负面影响。
Solitary splenic metastases are a rare occurrence, and the nasopharyngeal carcinoma represents one of the most uncommon primary sources. The present study aimed to describe a rare case of a solitary single splenic metastasis from nasopharyngeal carcinoma and to assess the number of cases of isolated nasopharyngeal carcinoma metastases to the spleen reported in the literature. We describe the case of a 56-year-old man with a history of nasopharyngeal carcinoma and complete remission after chemo-radiotherapy. Three months after complete remission, positron emission tomography/computed tomography scan revealed a hypermetabolic splenic lesion without increased metabolic activity in other areas. After laparoscopic splenectomy, the pathology report confirmed a single splenic metastasis from undifferentiated carcinoma of the nasopharyngeal type. The postoperative period was uneventful. We also performed a systematic review of the literature using MEDLINE and Google Scholar databases. All articles reporting cases of splenic metastases from nasopharyngeal carcinoma, with or without histologic confirmation, were evaluated. The literature search yielded 15 relevant articles, which were very heterogeneous in their aims and methods and described only 25 cases of splenic metastases from nasopharyngeal carcinoma. The present review shows that solitary splenic metastases from nasopharyngeal carcinoma are a rare event, but it should be considered in patients presenting with splenic lesions at imaging and a history of primary or recurrent nasopharyngeal carcinoma. No evidence supports a negative impact of splenectomy in patients with solitary splenic metastasis from nasopharyngeal carcinoma.