Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum malaria in Malian children
Association of Schistosoma haematobium infection with protection against acute Plasmodium falciparum malaria in Malian children
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DOI：
10.4269/ajtmh.2005.73.1124
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发表时间：
2005-12-01
影响因子：
3.3
通讯作者：
Doumbo, OK
中科院分区：
文献类型：
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作者：
Lyke, KE;Dicko, A;Doumbo, OK
恶性疟原虫和埃及血吸虫是世界范围内共同流行的寄生虫病。有证据表明蠕虫和疟疾感染之间存在相互作用，尽管尚不清楚这种作用对宿主是有益还是有害。将患有无症状吸血链球菌感染 (SP) (n = 338) 的 4-14 岁马里儿童按年龄、性别和居住地前瞻性地与已清除隐性肠道寄生虫的无血吸虫病 (SN) (n = 338) 的儿童进行匹配，并随访一个疟疾传播季节（25 周）。记录首次临床疟疾感染的时间、疟疾发作的发生率和寄生虫血症。观察到血吸虫病儿童的疟疾预防与年龄相关。与 SN 儿童相比，SP 儿童（4-8 岁）表现出首次临床疟疾感染的时间延迟（74 天与 59 天；P = 0.04）、疟疾发作次数较少（1.55 例与 1.81 例感染；P = 0.03）以及首次感染时几何平均寄生虫密度较低（6,359 例与 9,874 例无性形式/mm(3)；p = 0.07）。在 9-14 岁儿童中未观察到血吸虫病和恶性疟原虫疟疾之间的关联。我们的结论是，潜在的血吸虫病与预防临床恶性疟疾有关，且与年龄相关。
Plasmodium falciparum and Schistosoma haematobium are co-endemic parasitic diseases with worldwide distribution. Evidence suggests interactions occur between helminthic and malaria infections, although it is unclear whether this effect is beneficial or harmful to the host. Malian children 4-14 years of age with asymptomatic S. haematobilum infection (SP) (n = 338) were prospectively matched by age, sex, and residence to children without schistosomiasis (SN) (n = 338) who were cleared of occult intestinal parasites, and followed-up for one malaria transmission season (25 weeks). The time to the first clinical malaria infection, incidence of malaria episodes, and parasitemia were recorded. Age associated protection from malaria in children with schistosomiasis was observed. SP children (4-8 years of age) compared with SN children demonstrated delayed time to first clinical malaria infection (74 versus 59 days; P = 0.04), fewer numbers of malaria episodes (1.55 versus 1.81 infections; P = 0.03) and lower geometric mean parasite densities (6,359 versus 9,874 asexual forms/mm(3); p = 0.07) at first infection. No association between schistosomiasis and P. falciparum malaria was observed in children 9-14 years of age. We conclude that underlying schistosomiasis is associated with protection against clinical falciparum malaria in an age-dependent manner.