Effects of amlodipine and cilnidipine on cardiac sympathetic nervous system and neurohormonal status in essential hypertension
Effects of amlodipine and cilnidipine on cardiac sympathetic nervous system and neurohormonal status in essential hypertension
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DOI：
10.1161/01.hyp.33.6.1447
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发表时间：
1999-06-01
期刊：
影响因子：
8.3
通讯作者：
Miho, N
中科院分区：
文献类型：
--
作者：
Sakata, K;Shirotani, M;Miho, N
本研究旨在探讨氨氯地平和西尼地平对心脏交感神经系统和原发性高血压患者神经激素状态的影响。对47例轻度原发性高血压患者在给药前及给药后3个月行I-123-metaiodobenzylguanidine （MIBG）心脏显像并采血测定血浆肾素活性和血浆去甲肾上腺素浓度。24例患者接受5 ~ 10mg /d氨氯地平治疗；其余23例给予西尼地平10 ~ 20mg /d。为了比较，我们还研究了12名血压正常的受试者。两组高血压患者的基础特征无显著差异。在两组高血压患者中，收缩压和舒张压在药物治疗3个月后均显著降至相似水平。在药物治疗前，与正常组相比，2组高血压患者的冲洗率明显升高，心脏/纵隔（H/M）比明显降低。H/M比显著升高(P
N-Type calcium channel antagonists may suppress sympathetic activity, The purpose of this study was to assess the effects of amlodipine and cilnidipine on the cardiac sympathetic nervous system and the neurohormonal status of essential hypertension. I-123-metaiodobenzylguanidine (MIBG) cardiac imaging was performed and blood samples were taken to determine plasma renin activity and plasma norepinephrine concentration before and 3 months after drug administration in 47 patients with mild essential hypertension. Twenty-four of the patients were treated with 5 to 10 mg/d of amlodipine; the other 23 were treated with 10 to 20 mg/d of cilnidipine. For comparison, 12 normotensive subjects were also studied. No significant differences were found in the basal characteristics between the 2 hypertensive groups. In both hypertensive groups, both the systolic and diastolic blood pressures were significantly reduced to similar levels 3 months after drug treatment. Before the drug treatment, the 2 hypertensive groups had a significantly higher washout rate and lower heart-to-mediastinum (H/M) ratio compared with the normotensive subjects. The H/M ratio significantly increased (P