Emerging drugs for the treatment of diabetic ulcers.
Emerging drugs for the treatment of diabetic ulcers.
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DOI：
10.1517/14728214.2013.802305
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发表时间：
2013-06
影响因子：
3.4
通讯作者：
Veves A
中科院分区：
文献类型：
--
作者：
Tecilazich F;Dinh TL;Veves A
Diabetic ulcers are chronic non-healing ulcerations that despite the available medical tools still result in high amputation rates. Growing evidence suggests that alteration of the biochemical milieu of the chronic wound plays a significant role in diabetic wound healing impairment. The basic pathophysiology and the conventional treatment strategy of diabetic foot ulcers have been reviewed in the first section. In the second part we describe the most up-to-date bench and translational research in the field. The third section focuses on the drugs currently under development and the ongoing clinical trials evaluating their safety and efficacy. Finally, we analyze the major drug development issues and the possible scientific approaches to overcome them. Significant strides in understanding the chronic wound development have led to the development of topical therapies to address aberrant expression of growth factors and overexpression of inflammatory cytokines. Current research in our lab suggests that in while decreased growth factor expression occurs at the local wound level, increased systemic serum levels of growth factors suggest growth factor resistance.
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影响因子：
4.3
作者：
Arora, S;Pomposelli, F;Veves, A
通讯作者：
Veves, A
DOI：
10.1161/01.atv.0000201070.71787.b8
发表时间：
2006-03-01
影响因子：
8.7
作者：
Chang, YZ;Ceacareanu, B;Hassid, A
通讯作者：
Hassid, A
影响因子：
11.8
作者：
Cheng, A;Uetani, N;Tremblay, ML
通讯作者：
Tremblay, ML
影响因子：
7.7
作者：
Caballero, AE;Arora, S;Veves, A
通讯作者：
Veves, A
影响因子：
8
作者：
Boulton, AJM
通讯作者：
Boulton, AJM