Towards vast libraries of scaffold-diverse, conformationally constrained oligomers.
Towards vast libraries of scaffold-diverse, conformationally constrained oligomers.
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DOI：
10.1039/c6cc00617e
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发表时间：
2016-05-04
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影响因子：
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通讯作者：
McEnaney PJ
中科院分区：
文献类型：
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作者：
Kodadek T;McEnaney PJ
There is great interest in the development of probe molecules and drug leads that would bind tightly and selectively to protein surfaces that are difficult to target with traditional molecules, such as those involved in protein-protein interactions. The currently available evidence suggests that this will require molecules that are larger and have quite different chemical properties than typical Lipinski-compliant molecules that target enzyme active sites. We describe here efforts to develop vast libraries of conformationally constrained oligomers as a potentially rich source of these molecules.
