Detection of tobacco smoke deposition by hyperpolarized krypton-83 MRI
Detection of tobacco smoke deposition by hyperpolarized krypton-83 MRI
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DOI：
10.1016/j.mri.2007.06.009
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发表时间：
2008-02-01
影响因子：
2.5
通讯作者：
Meersmann, Thomas
中科院分区：
文献类型：
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作者：
Cleveland, Zackary I.;Pavlovskaya, Galina E.;Meersmann, Thomas
尽管肺中的烟草烟雾颗粒物对吸烟者肺部疾病的病因学很重要，但目前对颗粒沉积的空间分布或所产生的沉积物在人体中的持久性知之甚少，并且目前还没有令人满意的技术来直接观察气道中的烟草烟雾冷凝物。在这项原理验证工作中，引入超极化（hp）Kr-83 MRI和NMR光谱作为多孔介质中烟草烟雾沉积的探针。当氪气与暴露于香烟烟雾的表面接触时，观察到在接近环境的湿度、压力和温度条件下hp-Kr-83纵向（T-1）弛豫降低高达95%。在某些实验中，在涂有牛肺表面活性剂提取物的模型玻璃表面上观察到这种烟雾诱导的Kr-83自松弛加速。然而，没有观察到类似的效果，与hp-Pr-129表明，Kr-83的灵敏度烟雾沉积不是由顺磁性物质，而是由四极弛豫，由于高吸附亲和力的烟雾沉积物。烟雾处理和未处理表面之间的Kr-83 T-1差异足以在可变翻转角FLASH hp-Kr-83 MRI中产生强对比，表明hp-Kr-83可能是体内肺部MRI的有前途的造影剂。(C)2008年爱思唯尔公司All rights reserved.
Despite the importance of the tobacco smoke particulate matter in the lungs to the etiology of pulmonary disease in cigarette smokers, little is currently known about the spatial distribution of particle deposition or the persistence of the resulting deposits in humans, and no satisfactory technique currently exists to directly observe tobacco smoke condensate in airways. In this proof-of-principle work, hyperpolarized (hp) Kr-83 MRI and NMR spectroscopy are introduced as probes for tobacco smoke deposition in porous media. A reduction in the hp-Kr-83 longitudinal (T-1) relaxation of up to 95% under near-ambient humidity, pressure and temperature conditions was observed when the krypton gas was brought into contact with surfaces that had been exposed to cigarette smoke. This smoke-induced acceleration of the Kr-83 self-relaxation was observed for model glass surfaces that, in some experiments, were coated with bovine lung surfactant extract. However, a similar effect was not observed with hp-Xe-129 indicating that the Kr-83 sensitivity to smoke deposition was not caused by paramagnetic species but rather by quadrupolar relaxation due to high adsorption affinity for the smoke deposits. The Kr-83 T-1 differences between smoke-treated and untreated surfaces were sufficient to produce a strong contrast in variable flip angle FLASH hp-Kr-83 MRI, suggesting that hp-Kr-83 may be a promising contrast agent for in vivo pulmonary MRI. (C) 2008 Elsevier Inc. All rights reserved.