Induction of CD8+ T cell responses through targeting of antigen to Dectin-2
Induction of CD8+ T cell responses through targeting of antigen to Dectin-2
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DOI：
10.1016/j.cellimm.2006.05.001
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发表时间：
2006-02-01
影响因子：
4.3
通讯作者：
Tough, David F.
中科院分区：
文献类型：
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作者：
Carter, Robert W.;Thompson, Clare;Tough, David F.
将抗原靶向递送至树突状细胞（DC）可用于优化免疫。我们研究了是否可以通过将Ag靶向C型凝集素受体Dectin-2来提高诱导免疫应答的功效。当皮下注射抗Dectin-2 mAb时，在引流淋巴结中的低百分比DC上检测到mAb结合。与抗Dectin-2 mAb缀合的Ag在体内有效地呈递给CD 8（+）T细胞，并且在低剂量下引起CD 8（+）T细胞应答，其中游离Ag不能诱导应答。结果表明Dectin-2是一种潜在的免疫靶向分子。(c)2006年爱思唯尔公司All rights reserved.
Targeted delivery of antigens to dendritic cells (DC) can be used to optimise immunisation. We investigated whether the efficacy with which immune responses are induced can be improved by targeting Ags to a C-type lectin receptor, Dectin-2. When anti-Dectin-2 mAbs were injected s.c., mAb binding was detected on a low percentage of DC in the draining lymph node. Ag conjugated to anti-Dectin-2 mAbs was presented efficiently to CD8(+) T cells in vivo and elicited CD8(+) T cell responses at low doses where free Ag failed to induce a response. The results reveal Dectin-2 as a potential targeting molecule for immunisation. (c) 2006 Elsevier Inc. All rights reserved.