Role of Auditory Cortex in Noise- and Drug-Induced Tinnitus
Role of Auditory Cortex in Noise- and Drug-Induced Tinnitus
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DOI：
10.1044/1059-0889(2008/07-0025
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发表时间：
2008-12-01
影响因子：
1.8
通讯作者：
Eggermont, Jos J.
中科院分区：
文献类型：
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作者：
Eggermont, Jos J.
目的：阐明听觉皮质在耳鸣中的作用。方法：回顾噪声创伤或应用水杨酸盐和奎宁后猫听觉皮质的神经生理学改变。这些发现被解释在人类研究的背景下，特别是在患有耳鸣的人的大脑中。结果：耳鸣是一种听觉感知，听觉系统中的几个中枢结构可能对此起作用。因为中枢听觉系统既有前馈连接又有反馈连接，所以它可以被描述为一组嵌套的环路。一旦这些环路以一种病理性的方式被激活，就像它们可能在耳鸣中一样，就很难为每个起作用的结构分配重要性。结论：耳鸣不太可能是一组独立放电神经元的表达，而更有可能是一组神经元之间病理性同步性增强的结果。从诱发电位和神经元对同步测量中都有明确的证据表明这一点。
Purpose: To elucidate the role of auditory cortex in tinnitus.Method: Neurophysiological findings in cat auditory cortex following noise trauma or the application of salicylate and quinine, all expected to induce tinnitus, were reviewed. Those findings were interpreted in the context of what is expected from studies in humans, specifically in the brains of people with tinnitus.Results: Tinnitus is an auditory percept to which several central structures in the auditory system may contribute. Because the central auditory system has both feed-forward connections and feedback connections, it can be described as a set of nested loops. Once these loops become activated in a pathological fashion, as they may be in tinnitus, it becomes hard to assign importance to each contributing structure. Strongly interconnected networks, that is, neural assemblies, may be determining the quality of the tinnitus percept.Conclusion: It is unlikely that tinnitus is the expression of a set of independently firing neurons, and more likely that it is the result of a pathologically increased synchrony between sets of neurons. There is clear evidence for this from both evoked potentials and from neuron-pair synchrony measures.