Association between Dietary Tomato Intake and the Risk of Hepatocellular Carcinoma: The Singapore Chinese Health Study.
Association between Dietary Tomato Intake and the Risk of Hepatocellular Carcinoma: The Singapore Chinese Health Study.
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DOI：
10.1158/1055-9965.epi-20-0051
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Yuan JM
中科院分区：
文献类型：
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作者：
Thomas CE;Luu HN;Wang R;Adams-Haduch J;Jin A;Koh WP;Yuan JM
番茄和/或番茄红素的摄入与几种癌症的风险降低有关，但尚未有关于其与肝细胞癌风险之间关系的报道。在新加坡华人健康研究中，研究了番茄和番茄红素的摄入与患肝癌风险的关系，这是一项注册时年龄在45-74岁的63257名中国人的前瞻性队列研究。饮食使用经过验证的半定量食物频率问卷进行评估。在嵌套病例对照研究中，用Cox比例风险回归模型估计肝癌与番茄和番茄红素摄入量的危险比(HR)及其95%可信区间(CI)，用非条件Logistic回归分析乙肝表面抗原(HBs)阳性与肝癌的关系。经过平均17.6年的随访，确定了561例肝细胞癌病例。在调整潜在的混杂因素后，较高的番茄摄入量与较低的肝癌风险相关(P趋势<；0.001)。与最低四分位数相比，第二、第三和第四四分位番茄摄入量的肝细胞癌的HR(95%顺位)分别为0.70(0.56-0.88)、0.73(0.58-0.92)和0.63(0.49-0.81)。在HBs Ag阴性的个体中，这种负关联仍然存在(P趋势=0.03)。番茄红素摄入量与肝癌风险之间没有关联(P趋势=0.54)。摄入西红柿可能会预防肝癌的发展，特别是在没有慢性感染乙肝病毒的人中。摄入番茄是预防肝癌的一种低成本预防措施，由于非酒精性脂肪性肝病的发病率增加，这可能有助于降低风险。
Intake of tomato and/or lycopene has been associated with reduced risk of several cancers, but there is no report on the association with risk of hepatocellular carcinoma (HCC). The associations of tomato and lycopene consumption with risk of HCC were examined in the Singapore Chinese Health Study, a prospective cohort of 63,257 Chinese aged 45–74 years at enrollment. Diet was assessed using a validated semi-quantitative food frequency questionnaire. Cox proportional hazard regression models were used to estimate hazard ratio (HR) and its 95% confidence interval (CI) of HCC with the consumption of tomato and lycopene among all cohort participants, and unconditional logistic regression was used to assess the association by hepatitis B surface antigen (HBsAg) positivity in a nested case-control study. After a mean follow-up of 17.6 years, 561 incident HCC cases were identified. Higher tomato intake was associated with lower risk of HCC after adjustment for potential confounders (Ptrend<0.001). Compared to the lowest quartile, HRs (95% CIs) of HCC for the 2nd, 3rd, and 4th quartile of tomato intake were 0.70 (0.56–0.88), 0.73 (0.58–0.92), and 0.63 (0.49–0.81). Among HBsAg-negative individuals, the inverse association remained (Ptrend=0.03). There was no association between lycopene intake and HCC risk (Ptrend = 0.54). Tomato intake may offer protection against the development of HCC, particularly among individuals without chronic infection with hepatitis B virus. Tomato intake is a low-cost preventative measure against HCC that may help reduce risk due to increasing rates of non-alcoholic fatty liver disease.