Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathways.
Herpesvirus mRNAs are sorted for export via Crm1-dependent and -independent pathways.
复制标题
疱疹病毒 mRNA 通过 Crm1 依赖性和非依赖性途径进行分类并输出。
DOI：
10.1128/jvi.74.6.2814-2825.2000
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发表时间：
2000
影响因子：
5.4
通讯作者：
Silverstein,SJ
中科院分区：
文献类型：
--
作者：
Soliman,TM;Silverstein,SJ
Cellular pre-mRNA splicing is inhibited by ICP27, a herpes simplex virus regulatory protein, resulting in the shutoff of host protein synthesis. Here we reveal that ICP27 also mediates the export of some virus RNAs via a Crm1-dependent pathway and present evidence that independent domains are required for these functions. Sorting of some viral mRNAs for nuclear export requires Crm1, while other virus mRNAs are exported via another pathway.
